BAIT
CFTR
ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, tcag7.78
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
GO Process (9)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- cellular response to cAMP [ISS]
- chloride transmembrane transport [IDA, ISS, NAS, TAS]
- intracellular pH elevation [ISS]
- membrane hyperpolarization [ISS]
- positive regulation of voltage-gated chloride channel activity [IDA]
- respiratory gaseous exchange [TAS]
- sperm capacitation [ISS]
- transmembrane transport [TAS]
- transport [TAS]
Gene Ontology Molecular Function- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
AKAP6
ADAP100, ADAP6, AKAP100, PRKA6, mAKAP
A kinase (PRKA) anchor protein 6
GO Process (19)
GO Function (7)
GO Component (9)
Gene Ontology Biological Process
- action potential [IC]
- cAMP-mediated signaling [NAS]
- cellular response to cAMP [IDA]
- cellular response to cytokine stimulus [ISS]
- intracellular signal transduction [IBA]
- negative regulation of cAMP biosynthetic process [ISS]
- positive regulation of NFAT protein import into nucleus [ISS]
- positive regulation of calcineurin-NFAT signaling cascade [ISS]
- positive regulation of cell growth [ISS]
- positive regulation of cell growth involved in cardiac muscle cell development [ISS]
- positive regulation of delayed rectifier potassium channel activity [IDA]
- positive regulation of potassium ion transmembrane transport [IDA]
- positive regulation of protein phosphatase type 2B activity [ISS]
- positive regulation of release of sequestered calcium ion into cytosol [ISS]
- positive regulation of ryanodine-sensitive calcium-release channel activity [ISS]
- protein targeting [NAS]
- regulation of membrane repolarization [IDA]
- regulation of protein kinase A signaling [ISS]
- regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
The pathways that distinguish transport of folded and misfolded cargo through the exocytic (secretory) pathway of eukaryotic cells remain unknown. Using proteomics to assess global cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein interactions (the CFTR interactome), we show that Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR protein folding in the endoplasmic reticulum (ER). Cell-surface rescue of the most common ... [more]
Cell Nov. 17, 2006; 127(4);803-15 [Pubmed: 17110338]
Throughput
- High Throughput
Ontology Terms
- cell line: colorectal adenocarcinoma cell line (BTO:0001914) [colorectal cancer (DOID:9256)]
Additional Notes
- T84 cell
Curated By
- BioGRID