BAIT
CFTR
ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1, tcag7.78
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
GO Process (9)
GO Function (9)
GO Component (10)
Gene Ontology Biological Process
- cellular response to cAMP [ISS]
- chloride transmembrane transport [IDA, ISS, NAS, TAS]
- intracellular pH elevation [ISS]
- membrane hyperpolarization [ISS]
- positive regulation of voltage-gated chloride channel activity [IDA]
- respiratory gaseous exchange [TAS]
- sperm capacitation [ISS]
- transmembrane transport [TAS]
- transport [TAS]
Gene Ontology Molecular Function- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
- ATP-binding and phosphorylation-dependent chloride channel activity [TAS]
- PDZ domain binding [IDA]
- bicarbonate transmembrane transporter activity [ISS]
- channel-conductance-controlling ATPase activity [NAS]
- chloride channel activity [IDA]
- chloride channel inhibitor activity [IDA]
- chloride transmembrane transporter activity [ISS]
- enzyme binding [IPI]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
PREY
CDH1
AA960649, E-cad, Ecad, L-CAM, UVO, Um
cadherin 1
GO Process (30)
GO Function (10)
GO Component (26)
Gene Ontology Biological Process
- adherens junction organization [ISO]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- cellular response to amino acid stimulus [IDA]
- cellular response to indole-3-methanol [ISO]
- cellular response to lithium ion [ISO]
- cochlea development [IMP]
- epithelial cell morphogenesis [IMP]
- establishment of protein localization to plasma membrane [IDA, ISO]
- in utero embryonic development [IMP]
- intestinal epithelial cell development [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP]
- negative regulation of cell-cell adhesion [ISO]
- negative regulation of epithelial cell proliferation [IMP]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein homooligomerization [IDA]
- protein localization to plasma membrane [ISO]
- protein metabolic process [IDA]
- regulation of branching involved in salivary gland morphogenesis [IMP]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [IDA]
- regulation of neuron migration [IDA]
- regulation of protein localization [IMP]
- regulation of protein localization to cell surface [IMP]
- regulation of water loss via skin [IMP]
- salivary gland cavitation [IMP]
- sensory perception of sound [IMP]
- single organismal cell-cell adhesion [IMP, ISO]
- synapse assembly [ISO]
- tight junction assembly [IMP]
- trophectodermal cell differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Schmidt-Lanterman incisure [IDA]
- actin cytoskeleton [ISO]
- adherens junction [IDA]
- aggresome [ISO]
- apical junction complex [IDA, ISO]
- apical part of cell [IDA]
- axon [IDA]
- axon terminus [IDA]
- basolateral plasma membrane [IDA]
- catenin complex [IDA, ISO]
- cell junction [ISO]
- cell periphery [IDA]
- cell surface [IDA]
- cell-cell adherens junction [IDA, ISO]
- cell-cell junction [IDA, ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic side of plasma membrane [ISO]
- extracellular vesicular exosome [ISO]
- focal adhesion [ISO]
- integral component of membrane [ISO]
- lateral loop [IDA]
- lateral plasma membrane [ISO]
- node of Ranvier [IDA]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- trans-Golgi network [ISO]
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis.
The pathways that distinguish transport of folded and misfolded cargo through the exocytic (secretory) pathway of eukaryotic cells remain unknown. Using proteomics to assess global cystic fibrosis (CF) transmembrane conductance regulator (CFTR) protein interactions (the CFTR interactome), we show that Hsp90 cochaperones modulate Hsp90-dependent stability of CFTR protein folding in the endoplasmic reticulum (ER). Cell-surface rescue of the most common ... [more]
Cell Nov. 17, 2006; 127(4);803-15 [Pubmed: 17110338]
Throughput
- High Throughput
Ontology Terms
- cell line: colorectal adenocarcinoma cell line (BTO:0001914) [colorectal cancer (DOID:9256)]
Additional Notes
- T84 cell
Curated By
- BioGRID