SHANK3
Gene Ontology Biological Process
- MAPK cascade [IGI]
- N-methyl-D-aspartate receptor clustering [IMP]
- adult behavior [ISO]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clustering [IMP]
- brain morphogenesis [IMP]
- dendritic spine morphogenesis [IMP]
- embryonic epithelial tube formation [IGI]
- guanylate kinase-associated protein clustering [IMP]
- learning [IMP, ISO]
- locomotory exploration behavior [IMP]
- memory [IMP]
- negative regulation of actin filament bundle assembly [IDA]
- negative regulation of cell volume [IMP]
- neuromuscular process controlling balance [IMP]
- positive regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IMP]
- positive regulation of dendritic spine development [IMP]
- positive regulation of excitatory postsynaptic membrane potential [IMP]
- positive regulation of glutamate receptor signaling pathway [IMP, ISO]
- positive regulation of long-term neuronal synaptic plasticity [IMP]
- positive regulation of synapse structural plasticity [IMP]
- positive regulation of synaptic transmission, glutamatergic [IMP]
- postsynaptic density assembly [IMP]
- protein oligomerization [ISO]
- regulation of behavioral fear response [IMP]
- regulation of dendritic spine morphogenesis [IMP]
- regulation of grooming behavior [IMP]
- regulation of long term synaptic depression [IMP]
- regulation of long-term synaptic potentiation [IMP]
- social behavior [IMP, ISO]
- striatal medium spiny neuron differentiation [IMP]
- synapse assembly [IMP]
- vocal learning [ISO]
- vocalization behavior [IMP, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
RET
Gene Ontology Biological Process
- MAPK cascade [IGI]
- Peyer's patch morphogenesis [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- anatomical structure morphogenesis [TAS]
- cellular response to retinoic acid [ISO]
- embryonic epithelial tube formation [IDA, IGI]
- enteric nervous system development [IMP]
- innervation [ISO]
- membrane protein proteolysis [ISO]
- nervous system development [IMP]
- neural crest cell migration [IMP]
- neuron cell-cell adhesion [IDA, ISO]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- peptidyl-tyrosine phosphorylation [TAS]
- positive regulation of cell adhesion mediated by integrin [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell size [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- positive regulation of metanephric glomerulus development [IMP]
- positive regulation of neuron maturation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of axonogenesis [IMP]
- regulation of cell adhesion [ISO]
- response to pain [IMP]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IGI]
- ureter maturation [IMP]
- ureteric bud development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The neuronal scaffold protein Shank3 mediates signaling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
Shank proteins, initially also described as ProSAP proteins, are scaffolding adaptors that have been previously shown to integrate neurotransmitter receptors into the cortical cytoskeleton at postsynaptic densities. We show here that Shank proteins are also crucial in receptor tyrosine kinase signaling. The PDZ domain-containing Shank3 protein was found to represent a novel interaction partner of the receptor tyrosine kinase Ret, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID