TANC1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GRIA1
Gene Ontology Biological Process
- cellular response to amine stimulus [IEP]
- cellular response to amino acid stimulus [IEP]
- cellular response to dsRNA [IEP]
- cellular response to growth factor stimulus [IEP]
- cellular response to organic cyclic compound [IEP]
- cellular response to peptide hormone stimulus [IEP]
- ion transmembrane transport [IBA]
- ionotropic glutamate receptor signaling pathway [IDA, ISO]
- long term synaptic depression [ISO]
- long-term memory [IMP, ISO]
- neuronal action potential [IMP]
- positive regulation of membrane potential [IMP]
- positive regulation of synaptic transmission [IMP]
- receptor internalization [IDA, ISO]
- regulation of receptor recycling [IMP]
- regulation of synaptic plasticity [IMP, NAS]
- regulation of synaptic transmission [IDA]
- response to arsenic-containing substance [IEP]
- response to cocaine [IEP]
- response to drug [IEP]
- response to electrical stimulus [IEP]
- response to estradiol [IEP]
- response to fungicide [IEP]
- response to lithium ion [IEP]
- response to organic cyclic compound [IEP]
- response to peptide hormone [IEP]
- response to toxic substance [IMP]
- spinal cord development [IEP]
- synaptic transmission [ISO]
- synaptic transmission, glutamatergic [NAS]
Gene Ontology Molecular Function- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
- G-protein alpha-subunit binding [IPI]
- G-protein beta-subunit binding [IDA]
- PDZ domain binding [IPI]
- adenylate cyclase binding [IDA]
- alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [IDA, ISO]
- beta-2 adrenergic receptor binding [IPI]
- extracellular-glutamate-gated ion channel activity [IBA]
- identical protein binding [IPI]
- ionotropic glutamate receptor activity [IDA]
- myosin V binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein homodimerization activity [TAS]
- protein kinase A binding [IDA]
- protein kinase binding [IPI]
- small GTPase binding [IPI]
Gene Ontology Cellular Component
- alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex [IDA, ISO]
- asymmetric synapse [IDA]
- axonal spine [ISO]
- cell surface [IDA, ISO]
- cytosol [IDA]
- dendrite [ISO, ISS]
- dendrite membrane [ISO]
- dendritic shaft [IDA]
- dendritic spine [IDA, ISO]
- dendritic spine membrane [ISO]
- early endosome [IDA]
- endoplasmic reticulum [ISO]
- excitatory synapse [IDA]
- ionotropic glutamate receptor complex [ISO, TAS]
- membrane [ISO]
- neuromuscular junction [IDA]
- neuron projection [IDA, ISO]
- neuron spine [IDA, ISO]
- neuronal cell body [IDA, ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IBA, ISO]
- protein complex [IDA]
- recycling endosome [ISO]
- synapse [IDA, IMP, ISO]
- synaptic vesicle [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A novel scaffold protein, TANC, possibly a rat homolog of Drosophila rolling pebbles (rols), forms a multiprotein complex with various postsynaptic density proteins.
We cloned from the rat brain a novel gene, tanc (GenBank Accession No. AB098072), which encoded a protein containing three tetratricopeptide repeats (TPRs), ten ankyrin repeats and a coiled-coil region, and is possibly a rat homolog of Drosophila rolling pebbles (rols). The tanc gene was expressed widely in the adult rat brain. Subcellular distribution, immunohistochemical study of the brain and ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 9.
Curated By
- BioGRID