BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ACVR1
activin A receptor, type I
GO Process (38)
GO Function (12)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [ISO]
- G1/S transition of mitotic cell cycle [ISO]
- activin receptor signaling pathway [ISO]
- atrial septum primum morphogenesis [ISO]
- cardiac muscle cell fate commitment [ISO]
- cellular response to glucocorticoid stimulus [IEP]
- determination of left/right symmetry [ISO]
- embryonic heart tube morphogenesis [ISO]
- endocardial cushion cell fate commitment [ISO]
- gastrulation [ISO]
- gastrulation with mouth forming second [ISO]
- germ cell development [ISO]
- heart development [ISO]
- in utero embryonic development [ISO]
- mesoderm development [ISO]
- mesoderm formation [ISO]
- mitral valve morphogenesis [ISO]
- negative regulation of activin receptor signaling pathway [ISO]
- negative regulation of extrinsic apoptotic signaling pathway [ISO]
- negative regulation of signal transduction [ISO]
- neural crest cell migration [ISO]
- pathway-restricted SMAD protein phosphorylation [ISO]
- patterning of blood vessels [ISO]
- peptidyl-threonine phosphorylation [ISO]
- pharyngeal system development [ISO]
- positive regulation of bone mineralization [ISO]
- positive regulation of determination of dorsal identity [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein phosphorylation [IMP, ISO, TAS]
- regulation of ossification [ISO]
- regulation of skeletal muscle tissue development [IEP]
- signal transduction by phosphorylation [IMP]
- smooth muscle cell differentiation [ISO]
- transforming growth factor beta receptor signaling pathway [IMP, ISO]
- urogenital system development [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- SMAD binding [IMP, ISO]
- activin binding [ISO]
- activin receptor activity, type I [IDA, IMP, ISO]
- growth factor binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [IMP]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transmembrane receptor protein serine/threonine kinase activity [TAS]
- ATP binding [ISO]
- SMAD binding [IMP, ISO]
- activin binding [ISO]
- activin receptor activity, type I [IDA, IMP, ISO]
- growth factor binding [ISO]
- protein homodimerization activity [ISO]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [ISO]
- receptor signaling protein serine/threonine kinase activity [IMP]
- transforming growth factor beta binding [ISO]
- transforming growth factor beta receptor activity, type I [ISO]
- transmembrane receptor protein serine/threonine kinase activity [TAS]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis.
Protein ubiquitination is an essential post-translational modification regulating neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation contributes to the pathogenesis of neurological diseases. Here we report a systematic analysis of ubiquitinated proteome (ubiquitome) in rat brain using a newly developed monoclonal antibody that recognizes the diglycine tag on lysine residues in trypsinized peptides (K-GG peptides). Initial antibody specificity analysis ... [more]
J. Proteome Res. Aug. 15, 2012; 0(0); [Pubmed: 22871113]
Throughput
- Low Throughput
Curated By
- BioGRID