BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
IDE
INSDEGM
insulin degrading enzyme
GO Process (17)
GO Function (14)
GO Component (10)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- beta-amyloid metabolic process [IMP, ISO, ISS]
- bradykinin catabolic process [ISO, ISS]
- cellular protein catabolic process [IDA]
- determination of adult lifespan [ISO]
- hormone catabolic process [IDA]
- insulin catabolic process [ISO]
- insulin metabolic process [ISO]
- negative regulation of proteolysis [IDA]
- peptide catabolic process [TAS]
- positive regulation of protein oligomerization [ISO]
- protein heterooligomerization [IDA]
- protein homooligomerization [ISO]
- protein homotetramerization [IDA]
- proteolysis [ISO]
- proteolysis involved in cellular protein catabolic process [IMP, ISO]
- ubiquitin homeostasis [ISO]
Gene Ontology Molecular Function- ATP binding [IMP, IPI, ISO, ISS]
- ATPase activity [IDA]
- beta-amyloid binding [IPI]
- beta-endorphin binding [IMP]
- glycoprotein binding [ISO]
- insulin binding [IMP, ISO]
- metalloendopeptidase activity [IDA, IMP, ISO, ISS]
- peptidase activity [TAS]
- peptide binding [ISO]
- peptide hormone binding [IPI]
- protein homodimerization activity [IDA, ISO]
- receptor binding [ISO]
- ubiquitin binding [ISO]
- zinc ion binding [IMP, ISO, ISS]
- ATP binding [IMP, IPI, ISO, ISS]
- ATPase activity [IDA]
- beta-amyloid binding [IPI]
- beta-endorphin binding [IMP]
- glycoprotein binding [ISO]
- insulin binding [IMP, ISO]
- metalloendopeptidase activity [IDA, IMP, ISO, ISS]
- peptidase activity [TAS]
- peptide binding [ISO]
- peptide hormone binding [IPI]
- protein homodimerization activity [IDA, ISO]
- receptor binding [ISO]
- ubiquitin binding [ISO]
- zinc ion binding [IMP, ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis.
Protein ubiquitination is an essential post-translational modification regulating neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation contributes to the pathogenesis of neurological diseases. Here we report a systematic analysis of ubiquitinated proteome (ubiquitome) in rat brain using a newly developed monoclonal antibody that recognizes the diglycine tag on lysine residues in trypsinized peptides (K-GG peptides). Initial antibody specificity analysis ... [more]
J. Proteome Res. Aug. 15, 2012; 0(0); [Pubmed: 22871113]
Throughput
- Low Throughput
Curated By
- BioGRID