BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MADD
MAP-kinase activating death domain
GO Process (11)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- activation of MAPK activity [ISO, ISS]
- execution phase of apoptosis [ISO]
- negative regulation of apoptotic signaling pathway [ISO]
- negative regulation of growth hormone secretion [IDA]
- negative regulation of pancreatic amylase secretion [IMP]
- positive regulation of Rab GTPase activity [ISO]
- regulation of Rab protein signal transduction [ISO]
- regulation of apoptotic process [ISO]
- regulation of cell cycle [ISO, ISS]
- regulation of extrinsic apoptotic signaling pathway [ISO]
- regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO, ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis.
Protein ubiquitination is an essential post-translational modification regulating neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation contributes to the pathogenesis of neurological diseases. Here we report a systematic analysis of ubiquitinated proteome (ubiquitome) in rat brain using a newly developed monoclonal antibody that recognizes the diglycine tag on lysine residues in trypsinized peptides (K-GG peptides). Initial antibody specificity analysis ... [more]
J. Proteome Res. Aug. 15, 2012; 0(0); [Pubmed: 22871113]
Throughput
- Low Throughput
Curated By
- BioGRID