BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
MAGI2
Acvrinp1, Acvrip1, S-SCAM
membrane associated guanylate kinase, WW and PDZ domain containing 2
GO Process (17)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein signal transduction [ISO, ISS]
- cellular response to nerve growth factor stimulus [IDA]
- cytoplasmic transport [IMP]
- glomerular filtration [IC]
- glomerular visceral epithelial cell development [IEP]
- mitotic cell cycle arrest [IDA]
- negative regulation of activin receptor signaling pathway [ISO, ISS]
- negative regulation of cell migration [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of protein kinase B signaling [ISO, ISS]
- nerve growth factor signaling pathway [IDA]
- positive regulation of neuron projection development [IMP]
- positive regulation of phosphoprotein phosphatase activity [ISO, ISS]
- positive regulation of receptor internalization [ISO, ISS]
- protein heterooligomerization [IDA]
- receptor clustering [IDA]
- signal transduction [ISO]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- SMAD binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- phosphatase binding [ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [ISO, ISS]
- signal transducer activity [ISO, ISS]
- type II activin receptor binding [ISO, ISS]
- PDZ domain binding [IPI]
- SMAD binding [ISO, ISS]
- beta-1 adrenergic receptor binding [ISO, ISS]
- phosphatase binding [ISO, ISS]
- protein binding [IPI]
- protein complex binding [IPI]
- receptor signaling complex scaffold activity [ISO, ISS]
- signal transducer activity [ISO, ISS]
- type II activin receptor binding [ISO, ISS]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis.
Protein ubiquitination is an essential post-translational modification regulating neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation contributes to the pathogenesis of neurological diseases. Here we report a systematic analysis of ubiquitinated proteome (ubiquitome) in rat brain using a newly developed monoclonal antibody that recognizes the diglycine tag on lysine residues in trypsinized peptides (K-GG peptides). Initial antibody specificity analysis ... [more]
J. Proteome Res. Aug. 15, 2012; 0(0); [Pubmed: 22871113]
Throughput
- Low Throughput
Curated By
- BioGRID