BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
FIS1
Ttc11
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GO Process (18)
GO Function (1)
GO Component (6)
Gene Ontology Biological Process
- calcium-mediated signaling using intracellular calcium source [ISO]
- mitochondrial fission [ISO, ISS]
- mitochondrial fragmentation involved in apoptotic process [ISO, ISS]
- mitochondrial fusion [ISO, ISS]
- mitochondrion degradation [ISO]
- mitochondrion morphogenesis [ISO]
- negative regulation of endoplasmic reticulum calcium ion concentration [ISO]
- peroxisome fission [ISO, ISS]
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- positive regulation of cytosolic calcium ion concentration [ISO]
- positive regulation of intrinsic apoptotic signaling pathway [ISO]
- positive regulation of mitochondrial calcium ion concentration [ISO]
- positive regulation of mitochondrial fission [ISO, ISS]
- positive regulation of protein targeting to membrane [ISO, ISS]
- protein homooligomerization [ISO]
- protein targeting to mitochondrion [ISO]
- regulation of mitochondrion organization [ISO]
- release of cytochrome c from mitochondria [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis.
Protein ubiquitination is an essential post-translational modification regulating neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation contributes to the pathogenesis of neurological diseases. Here we report a systematic analysis of ubiquitinated proteome (ubiquitome) in rat brain using a newly developed monoclonal antibody that recognizes the diglycine tag on lysine residues in trypsinized peptides (K-GG peptides). Initial antibody specificity analysis ... [more]
J. Proteome Res. Aug. 15, 2012; 0(0); [Pubmed: 22871113]
Throughput
- Low Throughput
Curated By
- BioGRID