BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
NLGN2
neuroligin 2
GO Process (24)
GO Function (4)
GO Component (6)
Gene Ontology Biological Process
- gephyrin clustering [ISO, ISS]
- jump response [IMP]
- locomotory exploration behavior [ISO, ISS]
- metabolic process [IBA]
- neuromuscular process controlling balance [ISO, ISS]
- neuron cell-cell adhesion [IDA]
- positive regulation of excitatory postsynaptic membrane potential [ISO, ISS]
- positive regulation of inhibitory postsynaptic membrane potential [IMP, ISO]
- positive regulation of synapse assembly [IDA]
- positive regulation of synaptic transmission, GABAergic [ISO, ISS]
- positive regulation of synaptic transmission, glutamatergic [ISO, ISS]
- postsynaptic density protein 95 clustering [ISO, ISS]
- postsynaptic membrane assembly [ISO, ISS]
- presynaptic membrane assembly [IDA, ISO]
- protein localization to synapse [ISO, ISS]
- regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity [ISO, ISS]
- regulation of respiratory gaseous exchange by neurological system process [ISO, ISS]
- regulation of synaptic transmission [IBA, ISO, ISS]
- sensory perception of pain [ISO, ISS]
- social behavior [IMP]
- synapse assembly [IDA]
- synapse organization [IDA]
- terminal button organization [IMP]
- thigmotaxis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis.
Protein ubiquitination is an essential post-translational modification regulating neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation contributes to the pathogenesis of neurological diseases. Here we report a systematic analysis of ubiquitinated proteome (ubiquitome) in rat brain using a newly developed monoclonal antibody that recognizes the diglycine tag on lysine residues in trypsinized peptides (K-GG peptides). Initial antibody specificity analysis ... [more]
J. Proteome Res. Aug. 15, 2012; 0(0); [Pubmed: 22871113]
Throughput
- Low Throughput
Curated By
- BioGRID