BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
ERBB3
nuc-ErbB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
GO Process (27)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- Schwann cell differentiation [ISO]
- axonogenesis [IEP]
- cellular response to insulin stimulus [IEP]
- circadian rhythm [IEP]
- cranial nerve development [ISO]
- endocardial cushion development [ISO]
- epidermal growth factor receptor signaling pathway [IMP]
- extrinsic apoptotic signaling pathway in absence of ligand [ISO]
- mammary gland involution [IEP]
- negative regulation of cell adhesion [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of secretion [ISO]
- negative regulation of signal transduction [ISO]
- neuron apoptotic process [ISO]
- odontogenesis [IEP]
- peptidyl-tyrosine phosphorylation [TAS]
- peripheral nervous system development [ISO]
- phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of glucose import [IMP]
- positive regulation of protein tyrosine kinase activity [ISO]
- regulation of cell proliferation [ISO]
- response to drug [IEP]
- response to wounding [IEP]
- signal transduction [ISO]
- skeletal muscle tissue development [IEP]
- tongue development [IEP]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
Gene Ontology Molecular Function- growth factor binding [ISO]
- identical protein binding [ISO]
- neuregulin binding [IMP]
- neuregulin receptor activity [IMP]
- protein heterodimerization activity [ISO]
- protein tyrosine kinase activator activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [TAS]
- growth factor binding [ISO]
- identical protein binding [ISO]
- neuregulin binding [IMP]
- neuregulin receptor activity [IMP]
- protein heterodimerization activity [ISO]
- protein tyrosine kinase activator activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [TAS]
Gene Ontology Cellular Component
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis.
Protein ubiquitination is an essential post-translational modification regulating neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation contributes to the pathogenesis of neurological diseases. Here we report a systematic analysis of ubiquitinated proteome (ubiquitome) in rat brain using a newly developed monoclonal antibody that recognizes the diglycine tag on lysine residues in trypsinized peptides (K-GG peptides). Initial antibody specificity analysis ... [more]
J. Proteome Res. Aug. 15, 2012; 0(0); [Pubmed: 22871113]
Throughput
- Low Throughput
Curated By
- BioGRID