BAIT
UBC
ubiquitin C
GO Process (2)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
CACNA1C
RATIVS302
calcium channel, voltage-dependent, L type, alpha 1C subunit
GO Process (19)
GO Function (9)
GO Component (17)
Gene Ontology Biological Process
- adult walking behavior [ISO]
- calcium ion import [IMP]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IMP, ISO]
- calcium ion-dependent exocytosis [ISO]
- cellular calcium ion homeostasis [ISO]
- glucose homeostasis [ISO]
- growth hormone secretion [ISO]
- insulin secretion [ISO]
- membrane depolarization during action potential [IBA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- regulation of blood pressure [ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of organ growth [ISO]
- regulation of vasoconstriction [ISO]
- smooth muscle contraction [ISO]
- smooth muscle contraction involved in micturition [ISO]
- synaptic transmission [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- high voltage-gated calcium channel activity [IDA, IMP]
- ion channel binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein phosphatase 2A binding [IPI]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
- alpha-actinin binding [ISO]
- calmodulin binding [ISO]
- enzyme binding [ISO]
- high voltage-gated calcium channel activity [IDA, IMP]
- ion channel binding [IPI]
- protein binding [IPI]
- protein domain specific binding [IPI]
- protein phosphatase 2A binding [IPI]
- voltage-gated calcium channel activity [IDA, IMP, ISO, TAS]
Gene Ontology Cellular Component
- T-tubule [IDA, TAS]
- Z disc [IDA, ISO]
- caveolar macromolecular signaling complex [ISO]
- cell [ISO]
- cytoplasm [ISO]
- dendrite [IDA]
- dendritic shaft [ISO]
- integral component of membrane [ISO]
- membrane [IDA, ISO]
- neuronal cell body [IDA, ISO]
- nucleus [IDA]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO]
- presynaptic membrane [IDA]
- protein complex [IDA]
- sarcolemma [IDA]
- voltage-gated calcium channel complex [IC, IDA, ISO, TAS]
Rattus norvegicus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Synaptic Protein Ubiquitination in Rat Brain Revealed by Antibody-based Ubiquitome Analysis.
Protein ubiquitination is an essential post-translational modification regulating neurodevelopment, synaptic plasticity, learning, and memory, and its dysregulation contributes to the pathogenesis of neurological diseases. Here we report a systematic analysis of ubiquitinated proteome (ubiquitome) in rat brain using a newly developed monoclonal antibody that recognizes the diglycine tag on lysine residues in trypsinized peptides (K-GG peptides). Initial antibody specificity analysis ... [more]
J. Proteome Res. Aug. 15, 2012; 0(0); [Pubmed: 22871113]
Throughput
- Low Throughput
Curated By
- BioGRID