GATA6
Gene Ontology Biological Process
- Clara cell differentiation [IGI]
- Type II pneumocyte differentiation [IGI]
- cardiac muscle cell differentiation [IGI, IMP]
- cardiac muscle hypertrophy in response to stress [IMP]
- cardiac muscle tissue development [IGI]
- cardiac vascular smooth muscle cell differentiation [ISO]
- cellular response to BMP stimulus [IDA]
- cellular response to gonadotropin stimulus [IDA]
- cellular response to hypoxia [ISO]
- endodermal cell differentiation [IMP]
- endodermal cell fate determination [IDA]
- epithelial cell differentiation [IMP]
- in utero embryonic development [IMP]
- intestinal epithelial cell differentiation [ISO]
- liver development [IMP]
- lung saccule development [IGI]
- negative regulation of apoptotic process [ISO]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- negative regulation of transforming growth factor beta1 production [ISO]
- negative regulation of transforming growth factor beta2 production [ISO]
- organ formation [IMP]
- outflow tract septum morphogenesis [ISO]
- pancreas development [IMP]
- pancreatic A cell differentiation [IMP]
- phospholipid metabolic process [IGI]
- positive regulation of BMP signaling pathway [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of cardiac muscle cell proliferation [IGI]
- positive regulation of cell cycle arrest [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of gene expression [IGI]
- response to drug [ISO]
- response to estrogen [IDA]
- response to growth factor [ISO]
- smooth muscle cell differentiation [ISO]
- transcription from RNA polymerase II promoter [IDA, ISO]
- tube morphogenesis [IGI]
- type B pancreatic cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- RNA polymerase II repressing transcription factor binding [IPI]
- chromatin binding [IDA]
- double-stranded DNA binding [ISO]
- enhancer sequence-specific DNA binding [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
LMCD1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
LMCD1/Dyxin is a novel transcriptional cofactor that restricts GATA6 function by inhibiting DNA binding.
The activity of GATA factors is regulated, in part, at the level of protein-protein interactions. LIM domain proteins, first defined by the zinc finger motifs found in the Lin11, Isl-1, and Mec-3 proteins, act as coactivators of GATA function in both hematopoietic and cardiovascular tissues. We have identified a novel GATA-LIM interaction between GATA6 and LMCD1/dyxin. The LIM domains and ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GATA6 LMCD1 | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | - |
Curated By
- BioGRID