CALCOCO1
Gene Ontology Biological Process
- intracellular steroid hormone receptor signaling pathway [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of nucleic acid-templated transcription [IDA]
- signal transduction [IDA]
- transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- armadillo repeat domain binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription regulatory region DNA binding [ISO]
- armadillo repeat domain binding [ISO]
- beta-catenin binding [ISO]
- chromatin binding [IDA]
- ligand-dependent nuclear receptor transcription coactivator activity [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- sequence-specific DNA binding [ISO]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
AHR
Gene Ontology Biological Process
- B cell differentiation [TAS]
- B cell homeostasis [IMP, TAS]
- B-1 B cell homeostasis [TAS]
- T cell homeostasis [IMP]
- blood circulation [IMP]
- blood vessel development [IMP]
- blood vessel morphogenesis [IMP]
- blood vessel remodeling [IMP]
- camera-type eye development [IMP]
- cardiac left ventricle morphogenesis [IMP]
- cell morphogenesis [IMP]
- cellular response to cAMP [IDA]
- circadian regulation of gene expression [IDA]
- circumferential growth involved in left ventricle morphogenesis [IMP]
- common bile duct development [IMP]
- embryonic hemopoiesis [IMP]
- gland development [IMP]
- glomerulus morphogenesis [IMP]
- immune system process [IMP]
- intracellular receptor signaling pathway [IDA, ISO]
- kidney morphogenesis [IMP]
- liver development [IMP]
- lymphocyte homeostasis [IMP, TAS]
- negative regulation of necrotic cell death [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of vasoconstriction [IMP]
- ovarian follicle development [ISO]
- patterning of blood vessels [IMP]
- positive regulation of RNA polymerase II transcriptional preinitiation complex assembly [IDA]
- positive regulation of cell size [IMP]
- positive regulation of growth [IMP]
- positive regulation of transcription, DNA-templated [IDA]
- post-embryonic hemopoiesis [IMP]
- prostate gland development [IMP]
- regulation of B cell proliferation [ISO]
- regulation of blood pressure [TAS]
- regulation of blood vessel size [IMP]
- regulation of gene expression [ISO]
- regulation of heart growth [TAS]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription, DNA-templated [IDA, ISO, TAS]
- reproductive structure development [IMP]
- response to organic cyclic compound [ISO]
- response to stress [IDA]
- response to toxic substance [IDA, ISO]
- response to xenobiotic stimulus [IDA, ISO]
- smooth muscle tissue development [IMP]
- spleen development [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
- venous blood vessel development [IMP]
- xenobiotic metabolic process [TAS]
Gene Ontology Molecular Function- DNA binding [IDA, ISO]
- E-box binding [IDA]
- Hsp90 protein binding [ISO, TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor activity [ISO]
- enhancer binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- DNA binding [IDA, ISO]
- E-box binding [IDA]
- Hsp90 protein binding [ISO, TAS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- aryl hydrocarbon receptor activity [ISO]
- enhancer binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, ISO]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA, ISO, TAS]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Role of the coiled-coil coactivator (CoCoA) in aryl hydrocarbon receptor-mediated transcription.
The aryl hydrocarbon receptor (AHR) and AHR nuclear translocator (ARNT) are DNA binding transcription factors with basic helix-loop-helix/Per-Arnt-Sim (bHLH-PAS) domains. These two proteins form a heterodimer that mediates the toxic and biological effects of the environmental contaminant and AHR ligand 2,3,7,8-tetrachlorodibenzo-p-dioxin. The coiled-coil protein coiled-coil coactivator (Co-CoA) is a secondary coactivator for nuclear receptors and enhances nuclear receptor function by ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AHR CALCOCO1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID