BAIT
APOA1
apolipoprotein A-I
GO Process (44)
GO Function (12)
GO Component (16)
Gene Ontology Biological Process
- ERK1 and ERK2 cascade [IDA]
- G-protein coupled receptor signaling pathway [IDA]
- blood coagulation [TAS]
- cellular lipid metabolic process [TAS]
- cholesterol efflux [IDA]
- cholesterol homeostasis [IDA, IMP]
- cholesterol import [IMP]
- cholesterol metabolic process [IMP]
- cholesterol transport [IDA]
- high-density lipoprotein particle assembly [IDA]
- high-density lipoprotein particle clearance [IC]
- high-density lipoprotein particle remodeling [IC]
- integrin-mediated signaling pathway [IDA]
- lipoprotein metabolic process [TAS]
- negative chemotaxis [IDA]
- negative regulation of cell adhesion molecule production [IDA]
- negative regulation of cytokine secretion involved in immune response [IDA]
- negative regulation of heterotypic cell-cell adhesion [IDA]
- negative regulation of inflammatory response [IDA]
- negative regulation of interleukin-1 beta secretion [IDA]
- negative regulation of response to cytokine stimulus [IDA]
- negative regulation of tumor necrosis factor-mediated signaling pathway [IDA]
- negative regulation of very-low-density lipoprotein particle remodeling [IDA]
- peptidyl-methionine modification [IDA]
- phosphatidylcholine biosynthetic process [IDA]
- phospholipid efflux [IDA]
- phospholipid homeostasis [IDA]
- phototransduction, visible light [TAS]
- platelet activation [TAS]
- platelet degranulation [TAS]
- positive regulation of Rho protein signal transduction [IDA]
- positive regulation of cholesterol esterification [IDA]
- positive regulation of hydrolase activity [IDA]
- positive regulation of stress fiber assembly [IDA]
- positive regulation of substrate adhesion-dependent cell spreading [IDA]
- protein oxidation [IDA]
- protein stabilization [IDA]
- regulation of Cdc42 protein signal transduction [IDA]
- retinoid metabolic process [TAS]
- reverse cholesterol transport [IMP]
- small molecule metabolic process [TAS]
- transforming growth factor beta receptor signaling pathway [IDA]
- transmembrane transport [TAS]
- triglyceride homeostasis [IDA]
Gene Ontology Molecular Function- apolipoprotein A-I receptor binding [IPI]
- apolipoprotein receptor binding [IPI]
- beta-amyloid binding [IDA]
- chemorepellent activity [IDA]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA, IMP]
- enzyme binding [IPI]
- high-density lipoprotein particle receptor binding [IPI]
- identical protein binding [IPI]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
- apolipoprotein A-I receptor binding [IPI]
- apolipoprotein receptor binding [IPI]
- beta-amyloid binding [IDA]
- chemorepellent activity [IDA]
- cholesterol binding [IDA]
- cholesterol transporter activity [IDA, IMP]
- enzyme binding [IPI]
- high-density lipoprotein particle receptor binding [IPI]
- identical protein binding [IPI]
- phosphatidylcholine-sterol O-acyltransferase activator activity [IDA]
- phospholipid binding [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
- blood microparticle [IDA]
- cytoplasmic vesicle [IDA]
- cytosol [TAS]
- early endosome [TAS]
- endocytic vesicle [IDA]
- endocytic vesicle lumen [TAS]
- endoplasmic reticulum lumen [TAS]
- extracellular region [TAS]
- extracellular space [IDA, ISS]
- extracellular vesicular exosome [IDA]
- high-density lipoprotein particle [IDA]
- plasma membrane [TAS]
- secretory granule lumen [TAS]
- spherical high-density lipoprotein particle [IDA]
- very-low-density lipoprotein particle [IDA]
- vesicle [IDA]
Homo sapiens
PREY
APOD
apolipoprotein D
GO Process (20)
GO Function (3)
GO Component (8)
Gene Ontology Biological Process
- aging [NAS]
- angiogenesis [NAS]
- brain development [ISS]
- glucose metabolic process [IDA]
- lipid metabolic process [IDA]
- lipid transport [NAS]
- negative regulation of T cell migration [IDA]
- negative regulation of cytokine production involved in inflammatory response [IDA]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of lipoprotein lipid oxidation [IDA]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of protein import into nucleus [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of smooth muscle cell-matrix adhesion [IMP]
- peripheral nervous system axon regeneration [ISS]
- response to axon injury [ISS]
- response to drug [ISS]
- response to reactive oxygen species [IDA]
- tissue regeneration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-purification
An interaction is inferred from the identification of two or more protein subunits in a purified protein complex, as obtained by classical biochemical fractionation or affinity purification and one or more additional fractionation steps.
Publication
Distribution and localization of lecithin:cholesterol acyltransferase and cholesteryl ester transfer activity in A-I-containing lipoproteins.
Two types of A-I-containing lipoproteins are found in human high density lipoproteins (HDL): particles with A-II (Lp(A-I with A-II] and particles without A-II (Lp(A-I without A-II]. We have studied the distribution of lecithin:cholesterol acyltransferase (LCAT) and cholesteryl ester transfer (CET) activities in these particles. Lp(A-I with A-II) and Lp(A-I without A-II) particles were isolated from ten normolipidemic subjects by anti-A-I ... [more]
J. Lipid Res. Nov. 01, 1986; 27(11);1135-44 [Pubmed: 3104518]
Throughput
- Low Throughput
Ontology Terms
- tissue: blood (UBERON:0000178)
- tissue: blood (BTO:0000089)
Additional Notes
- affinity purification of APOA1 particles with (or without) APOA2 also brings down APO D lipoprotein
Curated By
- BioGRID