BAIT
RRM2
AA407299, R2
ribonucleotide reductase M2
GO Process (5)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
RRM1
RnrM1
ribonucleotide reductase M1
GO Process (4)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Enzymatically active mammalian ribonucleotide reductase exists primarily as an alpha6beta2 octamer.
Ribonucleotide reductase synthesizes deoxyribonucleotides, which are essential building blocks for DNA synthesis. The mammalian ribonucleotide reductase is described as an alpha(2)beta(2) complex consisting of R1 (alpha) and R2 (beta) proteins. ATP stimulates and dATP inhibits enzyme activity by binding to an allosteric site called the activity site on the R1 protein. Despite the opposite effects by ATP and dATP on ... [more]
J. Biol. Chem. Sep. 22, 2006; 281(38);27705-11 [Pubmed: 16861739]
Throughput
- Low Throughput
Curated By
- BioGRID