BAIT

NOVA1

9430099M15Rik, G630039L02, Nova-1
neuro-oncological ventral antigen 1
GO Process (3)
GO Function (3)
GO Component (3)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus
PREY

MATR3

1110061A14Rik, 2810017I02Rik, AI841759, AW555618, D030046F20Rik, mKIAA0723
matrin 3
GO Process (0)
GO Function (1)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

A brain-enriched polypyrimidine tract-binding protein antagonizes the ability of Nova to regulate neuron-specific alternative splicing.

Polydorides AD, Okano HJ, Yang YY, Stefani G, Darnell RB

The Nova paraneoplastic antigens are neuron-specific RNA binding proteins that participate in the control of alternative splicing. We have used the yeast two-hybrid system to isolate Nova interacting proteins and identify an RNA binding protein that is closely related to the polypyrimidine tract-binding protein (PTB). The expression of this protein, brPTB, is enriched in the brain, where it is expressed ... [more]

Proc. Natl. Acad. Sci. U.S.A. Jun. 06, 2000; 97(12);6350-5 [Pubmed: 10829067]

Throughput

  • Low Throughput

Curated By

  • BioGRID