BAIT
TYR
Oca1, albino, c, skc35
tyrosinase
GO Process (5)
GO Function (5)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RAB8A
AA409338, Mel
RAB8A, member RAS oncogene family
GO Process (15)
GO Function (6)
GO Component (21)
Gene Ontology Biological Process
- GTP catabolic process [IBA, ISO]
- Golgi vesicle fusion to target membrane [IBA, ISO]
- Rab protein signal transduction [IBA]
- axonogenesis [ISO]
- cellular response to insulin stimulus [IBA, ISO]
- cilium assembly [ISO]
- intracellular protein transport [IBA]
- protein localization to plasma membrane [IBA, ISO]
- protein secretion [IBA]
- regulation of exocytosis [IBA]
- regulation of long-term neuronal synaptic plasticity [ISO]
- regulation of protein localization [ISO]
- regulation of protein transport [ISO]
- synaptic vesicle exocytosis [IBA]
- vesicle docking involved in exocytosis [IBA, ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- centrosome [ISO]
- ciliary basal body [IDA]
- cilium [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [ISO]
- dendrite [ISO]
- extracellular vesicular exosome [ISO]
- neuronal cell body [ISO]
- nonmotile primary cilium [IDA, ISO]
- nucleolus [ISO]
- nucleoplasm [ISO]
- nucleus [ISO]
- phagocytic vesicle [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [ISO]
- primary cilium [ISO]
- recycling endosome [IDA]
- recycling endosome membrane [ISO]
- secretory granule membrane [IBA]
- synaptic vesicle [IBA]
- trans-Golgi network transport vesicle [IDA]
Mus musculus
Co-fractionation
Interaction inferred from the presence of two or more protein subunits in a partially purified protein preparation. If co-fractionation is demonstrated between 3 or more proteins, then add them as a complex.
Publication
Rab27a regulates the peripheral distribution of melanosomes in melanocytes.
Rab GTPases are regulators of intracellular membrane traffic. We report a possible function of Rab27a, a protein implicated in several diseases, including Griscelli syndrome, choroideremia, and the Hermansky-Pudlak syndrome mouse model, gunmetal. We studied endogenous Rab27a and overexpressed enhanced GFP-Rab27a fusion protein in several cultured melanocyte and melanoma-derived cell lines. In pigmented cells, we observed that Rab27a decorates melanosomes, whereas ... [more]
J. Cell Biol. Feb. 19, 2001; 152(4);795-808 [Pubmed: 11266470]
Throughput
- Low Throughput
Curated By
- BioGRID