BBS4
Gene Ontology Biological Process
- adult behavior [IMP]
- brain morphogenesis [IMP]
- centrosome organization [ISO]
- cerebral cortex development [IMP]
- cilium assembly [IMP]
- cilium morphogenesis [IMP]
- dendrite development [IMP]
- hippocampus development [IMP]
- leptin-mediated signaling pathway [IMP]
- maintenance of protein location in nucleus [ISO]
- metabolic process [ISO]
- microtubule anchoring at centrosome [ISO]
- microtubule cytoskeleton organization [IMP]
- mitotic cytokinesis [ISO]
- negative regulation of appetite by leptin-mediated signaling pathway [IMP]
- negative regulation of gene expression [IMP]
- negative regulation of systemic arterial blood pressure [IMP]
- neural tube closure [IMP]
- nonmotile primary cilium assembly [IMP]
- photoreceptor cell maintenance [IMP]
- positive regulation of cilium assembly [IMP]
- positive regulation of multicellular organism growth [IMP]
- protein localization [IMP]
- protein localization to centrosome [ISO]
- protein localization to organelle [IDA]
- regulation of cilium beat frequency involved in ciliary motility [IMP]
- regulation of cytokinesis [ISO]
- regulation of lipid metabolic process [IMP]
- response to leptin [IMP]
- retina homeostasis [IMP]
- retinal rod cell development [IMP]
- sensory perception of smell [IMP]
- spermatid development [IMP]
- striatum development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
FEZ1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Essential role for the Prader-Willi syndrome protein necdin in axonal outgrowth.
Necdin and Magel2 are related proteins inactivated in Prader-Willi syndrome (PWS), a sporadic chromosomal deletion disorder. We demonstrate that necdin and Magel2 bind to and prevent proteasomal degradation of Fez1, a fasciculation and elongation protein implicated in axonal outgrowth and kinesin-mediated transport, and also bind to the Bardet-Biedl syndrome (BBS) protein BBS4 in co-transfected cells. The interactions among necdin, Magel2, ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID