HOXA13
Gene Ontology Biological Process
- anatomical structure morphogenesis [IMP]
- artery morphogenesis [IMP]
- branching involved in prostate gland morphogenesis [IMP]
- embryonic forelimb morphogenesis [IMP]
- endothelial cell fate specification [IMP]
- endothelial cell morphogenesis [IMP]
- inner ear development [IMP]
- male genitalia development [IMP]
- organ morphogenesis [IMP]
- positive regulation of mesenchymal cell apoptotic process [IMP]
- positive regulation of mitosis [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- regulation of BMP signaling pathway [IMP]
- tissue homeostasis [IMP]
- vasculogenesis [IMP]
- ventricular septum development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MEIS1
Gene Ontology Biological Process
- angiogenesis [IMP]
- blood vessel morphogenesis [IMP]
- definitive hemopoiesis [IMP]
- hemopoiesis [IMP]
- lens morphogenesis in camera-type eye [IMP]
- megakaryocyte development [IMP]
- negative regulation of myeloid cell differentiation [IDA]
- negative regulation of neuron differentiation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription from RNA polymerase II promoter [IC]
- regulation of transcription, DNA-templated [IDA]
- transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA, IGI]
- DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [IDA]
- chromatin binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- sequence-specific DNA binding [IDA, IGI]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Range of HOX/TALE superclass associations and protein domain requirements for HOXA13:MEIS interaction.
AbdB-like HOX proteins form DNA-binding complexes with the TALE superclass proteins MEIS1A and MEIS1B, and trimeric complexes have been identified in nuclear extracts that include a second TALE protein, PBX. Thus, soluble DNA-independent protein-protein complexes exist in mammals. The extent of HOX/TALE superclass interactions, protein structural requirements, and sites of in vivo cooperative interaction have not been fully explored. We ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| HOXA13 MEIS1 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | 796774 |
Curated By
- BioGRID