FCER1G
Gene Ontology Biological Process
- Fc receptor mediated stimulatory signaling pathway [ISO]
- Fc-epsilon receptor signaling pathway [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [ISO]
- cell surface receptor signaling pathway [ISO]
- defense response to bacterium [ISO]
- immunoglobulin mediated immune response [ISO]
- integrin-mediated signaling pathway [ISO]
- mast cell activation [ISO]
- negative regulation of mast cell apoptotic process [ISO]
- neutrophil activation involved in immune response [ISO]
- neutrophil chemotaxis [ISO]
- phagocytosis, engulfment [ISO]
- positive regulation of immune response [ISO]
- positive regulation of interleukin-10 production [ISO]
- positive regulation of interleukin-6 production [ISO]
- positive regulation of mast cell cytokine production [ISO]
- positive regulation of mast cell degranulation [ISO]
- positive regulation of phagocytosis [ISO]
- positive regulation of tumor necrosis factor production [ISO]
- positive regulation of type I hypersensitivity [ISO]
- positive regulation of type III hypersensitivity [ISO]
- positive regulation of type IIa hypersensitivity [ISO]
- protein localization to plasma membrane [ISO]
- regulation of immune response [ISO]
- regulation of platelet activation [ISO]
- serotonin secretion by platelet [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PRKCD
Gene Ontology Biological Process
- B cell proliferation [ISO]
- aging [IEP]
- apoptotic process [ISO]
- aspartate transport [IMP]
- cellular response to glucose starvation [IEP]
- cellular response to insulin stimulus [IEP]
- cellular senescence [ISO]
- collagen metabolic process [IMP]
- defense response to bacterium [ISO, ISS]
- immunoglobulin mediated immune response [ISO]
- interleukin-10 production [ISO]
- interleukin-12 production [ISO]
- intracellular signal transduction [IDA]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of actin filament polymerization [ISO, ISS]
- negative regulation of filopodium assembly [ISO, ISS]
- negative regulation of glial cell apoptotic process [ISO, ISS]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of platelet aggregation [ISO, ISS]
- neutrophil activation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of ceramide biosynthetic process [ISO]
- positive regulation of glucose import [IMP]
- positive regulation of glucosylceramide catabolic process [ISO]
- positive regulation of phospholipid scramblase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of sphingomyelin catabolic process [ISO]
- positive regulation of superoxide anion generation [ISO, ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- response to amino acid [IEP]
- response to drug [IEP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to heat [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP]
- response to mechanical stimulus [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to oxidative stress [IMP]
- termination of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect.
The role of celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," in allergic inflammation was investigated. Celastrol decreased the secretion of beta-hexosaminidase, decreased the release of histamine, decreased the expression of Th2 cytokines and decreased calcium influx and cell adhesion in antigen-stimulated RBL2H3 cells. Exposure to celastrol decreased the phosphorylation of extracellular regulated kinase (ERK) and the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID