RAC1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [ISO]
- GTP catabolic process [IDA, ISO]
- Rac protein signal transduction [TAS]
- Wnt signaling pathway, planar cell polarity pathway [ISO]
- actin cytoskeleton organization [IDA, ISO]
- actin filament organization [IMP]
- actin filament polymerization [ISO]
- anatomical structure arrangement [ISO]
- auditory receptor cell morphogenesis [ISO]
- axon guidance [ISO]
- bone resorption [IDA]
- cell adhesion [ISO]
- cell migration [ISO]
- cell motility [ISO, ISS]
- cell proliferation [IMP]
- cell-cell junction organization [ISO]
- cellular component movement [IMP]
- cerebral cortex radially oriented cell migration [ISO]
- chemotaxis [IMP]
- cochlea morphogenesis [ISO]
- cytoskeleton organization [ISO]
- dendrite development [ISO]
- dendrite morphogenesis [ISO]
- dopaminergic neuron differentiation [ISO]
- embryonic olfactory bulb interneuron precursor migration [ISO]
- endocytosis [ISO]
- engulfment of apoptotic cell [ISO]
- epithelial cell morphogenesis [ISO]
- hyperosmotic response [ISO]
- lamellipodium assembly [ISO]
- localization within membrane [ISO]
- mast cell chemotaxis [IMP]
- negative regulation of interleukin-23 production [ISO]
- phagocytosis, engulfment [ISO]
- positive regulation of DNA replication [IMP]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell-substrate adhesion [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of lamellipodium assembly [ISO]
- positive regulation of neutrophil chemotaxis [ISO]
- positive regulation of phosphatidylinositol 3-kinase activity [ISO]
- positive regulation of protein phosphorylation [ISO, ISS]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein localization to plasma membrane [ISO]
- regulation of cell migration [ISO, ISS]
- regulation of respiratory burst [ISO]
- ruffle assembly [ISO]
- ruffle organization [ISO]
- semaphorin-plexin signaling pathway [IMP]
- small GTPase mediated signal transduction [ISO]
- substrate adhesion-dependent cell spreading [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi membrane [IDA]
- actin filament [ISO]
- cell projection [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [ISO]
- cytoplasmic ribonucleoprotein granule [ISO]
- cytoplasmic vesicle [IDA]
- cytosol [IDA]
- extracellular vesicular exosome [ISO]
- extrinsic component of plasma membrane [ISO]
- focal adhesion [ISO]
- lamellipodium [ISO]
- membrane [IDA, ISO]
- phagocytic cup [ISO]
- ruffle membrane [ISO]
- trans-Golgi network [ISO]
MAPK1
Gene Ontology Biological Process
- B cell receptor signaling pathway [ISO]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IMP, ISO]
- MAPK import into nucleus [IDA]
- T cell receptor signaling pathway [ISO]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [ISO]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [ISO]
- cellular response to organic substance [IDA]
- cytosine metabolic process [ISO]
- intracellular signal transduction [IDA, TAS]
- labyrinthine layer blood vessel development [ISO]
- lipopolysaccharide-mediated signaling pathway [ISO]
- mammary gland epithelial cell proliferation [ISO]
- negative regulation of cell differentiation [ISO]
- organ morphogenesis [ISO]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [ISO, ISS]
- positive regulation of cell migration [IEP]
- positive regulation of cell proliferation [IEP]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [IEP]
- positive regulation of translation [IMP]
- protein phosphorylation [IDA, ISO, TAS]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of protein stability [ISS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO, ISS]
- response to estrogen [IDA]
- response to exogenous dsRNA [ISO]
- response to lipopolysaccharide [ISO]
- response to toxic substance [IDA]
- sensory perception of pain [IMP]
- signal transduction [IDA]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
- ATP binding [IDA]
- MAP kinase activity [IDA, IMP, ISO, TAS]
- RNA polymerase II carboxy-terminal domain kinase activity [ISO]
- kinase activity [ISO, TAS]
- mitogen-activated protein kinase kinase kinase binding [IPI]
- phosphatase binding [ISO]
- phosphotyrosine binding [ISO]
- protein binding [IPI]
- protein kinase activity [ISO]
- protein kinase binding [IPI]
- protein serine/threonine kinase activity [IC, IDA, ISO, TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [IDA]
- caveola [TAS]
- cytoplasm [ISO, ISS]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [IDA]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [ISO, TAS]
- mitotic spindle [ISS]
- nucleoplasm [IDA, ISO, TAS]
- nucleus [IDA, ISO, TAS]
- perikaryon [IDA]
- protein complex [IDA]
- pseudopodium [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect.
The role of celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," in allergic inflammation was investigated. Celastrol decreased the secretion of beta-hexosaminidase, decreased the release of histamine, decreased the expression of Th2 cytokines and decreased calcium influx and cell adhesion in antigen-stimulated RBL2H3 cells. Exposure to celastrol decreased the phosphorylation of extracellular regulated kinase (ERK) and the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID