HSP90AA1
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- cardiac muscle cell apoptotic process [IEP]
- chaperone-mediated protein complex assembly [ISO]
- neuron migration [IMP]
- positive regulation of cardiac muscle contraction [IEP]
- positive regulation of cell size [IMP]
- positive regulation of lamellipodium assembly [IMP]
- positive regulation of nitric oxide biosynthetic process [ISO, ISS]
- positive regulation of protein import into nucleus, translocation [IMP]
- protein folding [TAS]
- protein import into mitochondrial outer membrane [ISO]
- regulation of catalytic activity [ISO, ISS]
- response to estrogen [IEP]
- response to heat [IEP]
- response to salt stress [IEP]
- skeletal muscle contraction [IEP]
Gene Ontology Molecular Function- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
- ATP binding [IDA]
- ATPase activity [ISO]
- CTP binding [IDA]
- GTP binding [IDA]
- MHC class II protein complex binding [ISO]
- Rho GDP-dissociation inhibitor binding [IDA]
- TPR domain binding [ISO, ISS]
- UTP binding [IDA]
- dATP binding [IDA]
- identical protein binding [ISO]
- ion channel binding [IPI]
- mRNA binding [IDA]
- nitric-oxide synthase regulator activity [ISO, ISS]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein kinase binding [IPI]
- protein phosphatase binding [IPI]
- sulfonylurea receptor binding [IPI]
- unfolded protein binding [TAS]
Gene Ontology Cellular Component
- apical plasma membrane [IDA]
- basolateral plasma membrane [IDA]
- brush border membrane [IDA]
- cell surface [IDA]
- cytoplasm [IDA, ISO]
- cytosol [IDA, ISO]
- extracellular matrix [IDA]
- extracellular vesicular exosome [ISO]
- intracellular [ISO]
- membrane [ISO]
- mitochondrion [ISO]
- myelin sheath [ISO]
- neuron projection [IDA]
- neuronal cell body [IDA]
- nucleoplasm [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [IDA]
- protein complex [IDA]
PRKCD
Gene Ontology Biological Process
- B cell proliferation [ISO]
- aging [IEP]
- apoptotic process [ISO]
- aspartate transport [IMP]
- cellular response to glucose starvation [IEP]
- cellular response to insulin stimulus [IEP]
- cellular senescence [ISO]
- collagen metabolic process [IMP]
- defense response to bacterium [ISO, ISS]
- immunoglobulin mediated immune response [ISO]
- interleukin-10 production [ISO]
- interleukin-12 production [ISO]
- intracellular signal transduction [IDA]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of actin filament polymerization [ISO, ISS]
- negative regulation of filopodium assembly [ISO, ISS]
- negative regulation of glial cell apoptotic process [ISO, ISS]
- negative regulation of insulin receptor signaling pathway [ISO]
- negative regulation of peptidyl-tyrosine phosphorylation [ISO]
- negative regulation of platelet aggregation [ISO, ISS]
- neutrophil activation [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of apoptotic signaling pathway [ISO]
- positive regulation of ceramide biosynthetic process [ISO]
- positive regulation of glucose import [IMP]
- positive regulation of glucosylceramide catabolic process [ISO]
- positive regulation of phospholipid scramblase activity [ISO]
- positive regulation of protein dephosphorylation [ISO]
- positive regulation of response to DNA damage stimulus [ISO]
- positive regulation of sphingomyelin catabolic process [ISO]
- positive regulation of superoxide anion generation [ISO, ISS]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA, ISO]
- response to amino acid [IEP]
- response to drug [IEP]
- response to ethanol [IEP]
- response to glucose [IEP]
- response to heat [IEP]
- response to hydrogen peroxide [IEP]
- response to hypoxia [IEP]
- response to mechanical stimulus [IEP]
- response to organic cyclic compound [IEP]
- response to organonitrogen compound [IEP]
- response to oxidative stress [IMP]
- termination of signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Celastrol binds to ERK and inhibits FcepsilonRI signaling to exert an anti-allergic effect.
The role of celastrol, a triterpene extracted from the Chinese "Thunder of God Vine," in allergic inflammation was investigated. Celastrol decreased the secretion of beta-hexosaminidase, decreased the release of histamine, decreased the expression of Th2 cytokines and decreased calcium influx and cell adhesion in antigen-stimulated RBL2H3 cells. Exposure to celastrol decreased the phosphorylation of extracellular regulated kinase (ERK) and the ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID