BAIT
MAPK1
9030612K14Rik, AA407128, AU018647, C78273, ERK, Erk2, MAPK2, PRKM2, Prkm1, p41mapk, p42mapk
mitogen-activated protein kinase 1
GO Process (35)
GO Function (12)
GO Component (18)
Gene Ontology Biological Process
- B cell receptor signaling pathway [IDA]
- ERBB signaling pathway [ISO]
- ERK1 and ERK2 cascade [ISO]
- MAPK cascade [IDA, IMP, ISO]
- MAPK import into nucleus [ISO]
- T cell receptor signaling pathway [IDA]
- caveolin-mediated endocytosis [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to granulocyte macrophage colony-stimulating factor stimulus [IDA]
- cellular response to organic substance [ISO]
- cytosine metabolic process [IDA]
- intracellular signal transduction [ISO]
- labyrinthine layer blood vessel development [IMP]
- lipopolysaccharide-mediated signaling pathway [IDA]
- mammary gland epithelial cell proliferation [IDA]
- negative regulation of cell differentiation [IGI]
- organ morphogenesis [IDA]
- peptidyl-serine phosphorylation [IDA, IMP, ISO]
- peptidyl-threonine phosphorylation [IDA]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of translation [ISO]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of Golgi inheritance [TAS]
- regulation of cytoskeleton organization [TAS]
- regulation of early endosome to late endosome transport [TAS]
- regulation of sequence-specific DNA binding transcription factor activity [NAS]
- regulation of stress-activated MAPK cascade [TAS]
- response to epidermal growth factor [ISO]
- response to estrogen [ISO]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to toxic substance [ISO]
- sensory perception of pain [ISO]
- signal transduction [ISO]
- transcription, DNA-templated [NAS]
Gene Ontology Molecular Function- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
- ATP binding [ISO]
- MAP kinase activity [IDA, IMP, ISO]
- RNA polymerase II carboxy-terminal domain kinase activity [IDA]
- kinase activity [IDA]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- phosphatase binding [ISO]
- phosphotyrosine binding [IMP]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [TAS]
- axon [ISO]
- caveola [TAS]
- cytoplasm [IDA, ISO]
- cytoskeleton [TAS]
- cytosol [IDA, ISO, TAS]
- dendrite cytoplasm [ISO]
- early endosome [TAS]
- extracellular vesicular exosome [ISO]
- focal adhesion [TAS]
- late endosome [TAS]
- microtubule cytoskeleton [ISO]
- mitochondrion [IDA, TAS]
- nucleoplasm [ISO]
- nucleus [IDA, ISO, TAS]
- perikaryon [ISO]
- protein complex [ISO]
- pseudopodium [IDA]
Mus musculus
PREY
FERT2
AV082135, C330004K01Rik, Fer, Fert
fer (fms/fps related) protein kinase, testis specific 2
GO Process (39)
GO Function (14)
GO Component (8)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [IMP]
- Kit signaling pathway [IMP]
- actin cytoskeleton reorganization [IMP]
- cell adhesion [IMP]
- cell proliferation [ISO]
- cell-cell adhesion mediated by cadherin [IMP]
- cellular response to insulin stimulus [IDA]
- cellular response to macrophage colony-stimulating factor stimulus [ISO]
- cellular response to reactive oxygen species [IMP]
- chemotaxis [IMP]
- cytokine-mediated signaling pathway [ISO]
- diapedesis [IMP]
- epidermal growth factor receptor signaling pathway [IBA]
- extracellular matrix-cell signaling [IMP]
- innate immune response [IBA]
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase [IDA]
- interleukin-6-mediated signaling pathway [ISO]
- microtubule cytoskeleton organization [ISO]
- mitotic cell cycle [ISO]
- negative regulation of mast cell activation involved in immune response [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell migration [ISO]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IDA]
- regulation of cell proliferation [IBA]
- regulation of epidermal growth factor receptor signaling pathway [ISO]
- regulation of fibroblast migration [IMP]
- regulation of lamellipodium assembly [ISO]
- regulation of mast cell degranulation [IBA]
- regulation of protein phosphorylation [IMP]
- response to lipopolysaccharide [IMP]
- response to platelet-derived growth factor [IDA]
- signal transduction [IDA]
- substrate adhesion-dependent cell spreading [IMP]
- tyrosine phosphorylation of Stat3 protein [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin binding [ISO]
- cadherin binding [ISO]
- cell adhesion molecule binding [ISO]
- cytoskeletal protein binding [ISO]
- epidermal growth factor receptor binding [ISO]
- gamma-catenin binding [ISO]
- lipid binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase 1 binding [IPI]
- receptor binding [IBA]
- Rab GTPase binding [ISO]
- actin binding [ISO]
- cadherin binding [ISO]
- cell adhesion molecule binding [ISO]
- cytoskeletal protein binding [ISO]
- epidermal growth factor receptor binding [ISO]
- gamma-catenin binding [ISO]
- lipid binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase 1 binding [IPI]
- receptor binding [IBA]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fer kinase sustains the activation level of ERK1/2 and increases the production of VEGF in hypoxic cells.
Fer is a nuclear and cytoplasmic tyrosine kinase that is ubiquitously expressed in mammalian cells. Herein we show that Fer sustains a key signaling step in hypoxic cells. Knock-down of the Fer protein using a specific siRNA decreased the production of VEGF by the hypoxic cells. Conversely, ectopic expression of this kinase led to an elevated production of VEGF under ... [more]
Cell. Signal. Mar. 01, 2005; 17(3);341-53 [Pubmed: 15567065]
Throughput
- Low Throughput
Curated By
- BioGRID