CNTF
Gene Ontology Biological Process
- JAK-STAT cascade [ISO]
- astrocyte activation [ISO]
- ciliary neurotrophic factor-mediated signaling pathway [ISO]
- membrane hyperpolarization [ISO]
- muscle organ morphogenesis [IGI]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of photoreceptor cell differentiation [IDA]
- nervous system development [ISO]
- neuron development [IGI]
- positive regulation of JAK-STAT cascade [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of axon regeneration [ISO]
- positive regulation of cell growth [ISO]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of hormone secretion [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of tyrosine phosphorylation of Stat3 protein [IDA, ISO]
- protein heterooligomerization [ISO]
- regulation of resting membrane potential [ISO]
- regulation of retinal cell programmed cell death [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CNTFR
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.
A structural profile-based computational screen was used to identify neuropoietin (NP), a new cytokine. The np gene is localized in tandem with the cardiotrophin-1 gene on mouse chromosome 7. NP shares structural and functional features with ciliary neurotrophic factor (CNTF), cardiotrophin-1, and cardiotrophin-like cytokine. It acts through a membrane receptor complex comprising CNTF receptor-alpha component (CNTFRalpha), gp130, and leukemia inhibitory ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID