BTK
Gene Ontology Biological Process
- B cell receptor signaling pathway [IBA]
- I-kappaB kinase/NF-kappaB signaling [IMP]
- adaptive immune response [IBA]
- cell maturation [IMP]
- cellular response to molecule of fungal origin [ISO]
- cellular response to reactive oxygen species [ISO]
- histamine secretion by mast cell [ISO]
- innate immune response [IBA]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA, ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA]
- regulation of cell proliferation [IBA]
- response to organic substance [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GNB1
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IDA, ISO, TAS]
- GTP catabolic process [ISA, ISO]
- cardiac muscle cell apoptotic process [ISO]
- cell proliferation [IDA]
- cellular response to hypoxia [ISO]
- phospholipase C-activating G-protein coupled receptor signaling pathway [IDA]
- phototransduction, visible light [ISA]
- positive regulation of cytosolic calcium ion concentration [ISO]
- retina development in camera-type eye [IMP]
- sensory perception of taste [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Binding of beta gamma subunits of heterotrimeric G proteins to the PH domain of Bruton tyrosine kinase.
Bruton tyrosine kinase (Btk) has been implicated as the defective gene in both human and murine B-cell deficiencies. The identification of molecules that interact with Btk may shed light on critical processes in lymphocyte development. The N-terminal unique region of Btk contains a pleckstrin homology domain. This domain is found in a broad array of signaling molecules and implicated to ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID