A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.

Publication

The exoribonuclease Dis3L2 defines a novel eukaryotic RNA degradation pathway.

Malecki M, Viegas SC, Carneiro T, Golik P, Dressaire C, Ferreira MG, Arraiano CM

The final step of cytoplasmic mRNA degradation proceeds in either a 5'-3' direction catalysed by Xrn1 or in a 3'-5' direction catalysed by the exosome. Dis3/Rrp44, an RNase II family protein, is the catalytic subunit of the exosome. In humans, there are three paralogues of this enzyme: DIS3, DIS3L, and DIS3L2. In this work, we identified a novel Schizosaccharomyces pombe ... [more]

EMBO J. Mar. 15, 2013; 0(0); [Pubmed: 23503588]

Throughput

Low Throughput

Ontology Terms

phenotype: inviable (APO:0000112)

Curated By

BioGRID

Interaction Summary

DIS32

Gene Ontology Biological Process

Gene Ontology Molecular Function

3'-5'-exoribonuclease activity [IDA]

Gene Ontology Cellular Component

EXO2