BAIT
MFF
C2orf33, GL004, AD030
mitochondrial fission factor
GO Process (13)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- mitochondrial fission [ISS]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- mitochondrial fusion [IMP]
- mitochondrion morphogenesis [IMP]
- peroxisome fission [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein targeting to membrane [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- protein homooligomerization [IDA]
- protein targeting to mitochondrion [IMP]
- regulation of mitochondrion organization [IMP]
- regulation of peroxisome organization [IMP]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
MFF
C2orf33, GL004, AD030
mitochondrial fission factor
GO Process (13)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
- mitochondrial fission [ISS]
- mitochondrial fragmentation involved in apoptotic process [IMP]
- mitochondrial fusion [IMP]
- mitochondrion morphogenesis [IMP]
- peroxisome fission [IMP]
- positive regulation of mitochondrial fission [IDA]
- positive regulation of protein targeting to membrane [IDA]
- positive regulation of release of cytochrome c from mitochondria [IMP]
- protein homooligomerization [IDA]
- protein targeting to mitochondrion [IMP]
- regulation of mitochondrion organization [IMP]
- regulation of peroxisome organization [IMP]
- release of cytochrome c from mitochondria [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission.
Mitochondrial fission is mediated by the dynamin-related GTPases Dnm1/Drp1 (yeast/mammals), which form spirals around constricted sites on mitochondria. Additional membrane-associated adaptor proteins (Fis1, Mdv1, Mff, and MiDs) are required to recruit these GTPases from the cytoplasm to the mitochondrial surface. Whether these adaptors participate in both GTPase recruitment and membrane scission is not known. Here we use a yeast strain ... [more]
Proc. Natl. Acad. Sci. U.S.A. Mar. 25, 2013; 0(0); [Pubmed: 23530241]
Throughput
- Low Throughput
Additional Notes
- analytical ultracentrifugation with purified proteins: homodimer
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MFF MFF | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | 2738569 |
Curated By
- BioGRID