CD3E
Gene Ontology Biological Process
- T cell costimulation [IGI]
- T cell receptor signaling pathway [IDA]
- apoptotic signaling pathway [IDA]
- cell surface receptor signaling pathway [IDA]
- lymphocyte activation [IMP]
- negative regulation of smoothened signaling pathway [IDA]
- negative thymic T cell selection [IDA]
- positive regulation of T cell activation [IDA]
- positive regulation of T cell anergy [IDA]
- positive regulation of T cell proliferation [IDA, ISO]
- positive regulation of alpha-beta T cell proliferation [IDA]
- positive regulation of calcium-mediated signaling [IDA]
- positive regulation of interferon-gamma production [IDA]
- positive regulation of interleukin-2 biosynthetic process [IDA]
- positive regulation of interleukin-4 production [IDA]
- positive regulation of peptidyl-tyrosine phosphorylation [IDA]
- response to nutrient [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
PTPN6
Gene Ontology Biological Process
- B cell receptor signaling pathway [IMP]
- abortive mitotic cell cycle [IMP]
- cell differentiation [ISO]
- cell proliferation [ISO]
- cytokine-mediated signaling pathway [TAS]
- hematopoietic progenitor cell differentiation [IMP]
- intracellular signal transduction [IDA]
- megakaryocyte development [IMP]
- natural killer cell mediated cytotoxicity [IMP]
- negative regulation of B cell receptor signaling pathway [IGI]
- negative regulation of MAP kinase activity [IMP]
- negative regulation of MAPK cascade [IMP]
- negative regulation of T cell proliferation [IMP]
- negative regulation of T cell receptor signaling pathway [IMP]
- negative regulation of humoral immune response mediated by circulating immunoglobulin [IMP]
- negative regulation of peptidyl-tyrosine phosphorylation [IMP, ISO]
- peptidyl-tyrosine dephosphorylation [IDA, ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet aggregation [IMP]
- platelet formation [IGI]
- positive regulation of cell adhesion mediated by integrin [IMP]
- positive regulation of cell proliferation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- protein dephosphorylation [IDA, IMP, ISO]
- regulation of B cell differentiation [IMP]
- regulation of ERK1 and ERK2 cascade [ISO]
- regulation of G1/S transition of mitotic cell cycle [ISO]
- regulation of release of sequestered calcium ion into cytosol [IGI]
- signal transduction [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase.
The association of PTP1C deficiency with the multiplicity of lymphoid cell abnormalities manifested by motheaten (me) and viable motheaten (me(v)) mice suggests a pivotal role for this tyrosine phosphatase in the regulation of lymphocyte differentiation and function. To delineate the relevance of PTP1C to T cell physiology, we have examined me and me(v) T cells with regards to their capacity ... [more]
Throughput
- High Throughput
Curated By
- BioGRID