KLHL24
GRIK2
Gene Ontology Biological Process
- behavioral fear response [IMP]
- cellular calcium ion homeostasis [IMP]
- intracellular protein transport [IDA]
- ion transmembrane transport [IGI]
- ionotropic glutamate receptor signaling pathway [IGI, ISO]
- negative regulation of neuron apoptotic process [IGI]
- negative regulation of synaptic transmission, glutamatergic [IGI, ISO]
- neuron apoptotic process [ISO]
- neuronal action potential [IMP]
- positive regulation of neuron apoptotic process [ISO]
- positive regulation of synaptic transmission [ISO]
- receptor clustering [ISO]
- regulation of JNK cascade [ISO]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of inhibitory postsynaptic membrane potential [IGI, IMP]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [IDA, IGI, IMP]
- regulation of short-term neuronal synaptic plasticity [IMP, ISO]
- regulation of synaptic transmission [ISO]
- signal transduction [ISO]
- synaptic transmission [IGI, IMP, ISO]
- synaptic transmission, glutamatergic [IMP]
Gene Ontology Molecular Function- PDZ domain binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IMP]
- kainate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase binding [ISO]
- PDZ domain binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate receptor activity [ISO]
- identical protein binding [ISO]
- ionotropic glutamate receptor activity [IMP]
- kainate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- axon [ISO]
- cell [IMP]
- dendrite [IBA, ISO]
- dendrite cytoplasm [ISO]
- integral component of plasma membrane [ISO]
- intracellular [IDA]
- ionotropic glutamate receptor complex [IC, ISO]
- kainate selective glutamate receptor complex [IPI]
- membrane [IDA]
- neuronal cell body [IDA]
- perikaryon [ISO]
- postsynaptic density [IDA]
- postsynaptic membrane [IDA]
- presynaptic membrane [IDA]
- synapse [IDA, ISO, TAS]
- terminal bouton [ISO]
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
KRIP6: a novel BTB/kelch protein regulating function of kainate receptors.
Whereas many interacting proteins have been identified for AMPA and NMDA glutamate receptors, fewer are known to directly bind and regulate function of kainate receptors. Using a yeast two-hybrid screen for interacting partners of the C-terminal domain of GluR6a, we identified a novel neuronal protein of the BTB/kelch family, KRIP6. KRIP6 binds to the GluR6a C-terminal domain at a site ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KLHL24 GRIK2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID