ACVR2A
Gene Ontology Biological Process
- BMP signaling pathway [IMP, ISO]
- Sertoli cell proliferation [IMP]
- activin receptor signaling pathway [ISO]
- anterior/posterior pattern specification [IGI]
- cellular response to BMP stimulus [ISO]
- determination of left/right symmetry [IGI]
- embryonic skeletal system development [IMP]
- gastrulation with mouth forming second [IGI]
- male gonad development [IMP]
- mesoderm development [IMP]
- penile erection [IMP]
- positive regulation of activin receptor signaling pathway [ISO]
- positive regulation of bone mineralization [ISO]
- positive regulation of erythrocyte differentiation [ISO]
- positive regulation of follicle-stimulating hormone secretion [ISO]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of protein phosphorylation [ISO]
- protein phosphorylation [ISO]
- regulation of BMP signaling pathway [IMP]
- regulation of nitric-oxide synthase activity [IMP]
- regulation of signal transduction [IDA]
- sperm ejaculation [IMP]
- spermatogenesis [IGI]
Gene Ontology Molecular Function- PDZ domain binding [IPI]
- activin binding [IPI, ISO]
- activin receptor activity, type II [ISO]
- activin-activated receptor activity [ISO]
- coreceptor activity [ISO]
- growth factor binding [IMP, IPI]
- inhibin binding [IPI, ISO]
- protein binding [IPI]
- protein self-association [IPI]
- protein serine/threonine kinase activity [ISO]
- PDZ domain binding [IPI]
- activin binding [IPI, ISO]
- activin receptor activity, type II [ISO]
- activin-activated receptor activity [ISO]
- coreceptor activity [ISO]
- growth factor binding [IMP, IPI]
- inhibin binding [IPI, ISO]
- protein binding [IPI]
- protein self-association [IPI]
- protein serine/threonine kinase activity [ISO]
Gene Ontology Cellular Component
MAGI2
Gene Ontology Biological Process
- SMAD protein signal transduction [IDA]
- cellular response to nerve growth factor stimulus [ISO]
- cytoplasmic transport [ISO]
- mitotic cell cycle arrest [ISO]
- negative regulation of activin receptor signaling pathway [IDA]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of protein kinase B signaling [ISO]
- nerve growth factor signaling pathway [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of receptor internalization [ISO]
- protein heterooligomerization [ISO]
- receptor clustering [ISO]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Identification and characterization of a PDZ protein that interacts with activin type II receptors.
We have identified a mouse PDZ protein that interacts with the activin type IIA receptor (ActRIIA), which we named activin receptor-interacting protein 1 (ARIP1). By using yeast two-hybrid screening, we isolated a cDNA clone of ARIP1 from a mouse brain cDNA library. We detected two forms of ARIP1, ARIP1-long and ARIP1-short, which may be produced by alternative splicing. ARIP1-long had ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ACVR2A MAGI2 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - | |
| MAGI2 ACVR2A | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID