BAIT
MAGI2
AIP-1, Acvri1, Acvrinp1, Acvrip1, Magi-2, S-SCAM, mKIAA0705
membrane associated guanylate kinase, WW and PDZ domain containing 2
GO Process (15)
GO Function (9)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein signal transduction [IDA]
- cellular response to nerve growth factor stimulus [ISO]
- cytoplasmic transport [ISO]
- mitotic cell cycle arrest [ISO]
- negative regulation of activin receptor signaling pathway [IDA]
- negative regulation of cell migration [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of protein kinase B signaling [ISO]
- nerve growth factor signaling pathway [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of phosphoprotein phosphatase activity [ISO]
- positive regulation of receptor internalization [ISO]
- protein heterooligomerization [ISO]
- receptor clustering [ISO]
- signal transduction [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SMAD3
AU022421, Madh3, RP23-63E8.1
SMAD family member 3
GO Process (73)
GO Function (31)
GO Component (11)
Gene Ontology Biological Process
- SMAD protein complex assembly [ISO]
- SMAD protein signal transduction [IGI]
- T cell activation [IMP]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [ISO]
- activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway [ISO]
- activin receptor signaling pathway [ISO]
- cell cycle arrest [ISO]
- cell-cell junction organization [ISO]
- developmental growth [IGI]
- embryonic cranial skeleton morphogenesis [IGI]
- embryonic foregut morphogenesis [IGI]
- embryonic pattern specification [IGI]
- endoderm development [IGI]
- evasion or tolerance of host defenses by virus [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- gastrulation [IGI]
- heart looping [IGI]
- immune response [ISO]
- immune system development [IGI]
- in utero embryonic development [IGI]
- intracellular signal transduction [ISO]
- lens fiber cell differentiation [IMP]
- liver development [IGI]
- mesoderm formation [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell growth [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of inflammatory response [IMP]
- negative regulation of mitotic cell cycle [ISO]
- negative regulation of osteoblast differentiation [IGI]
- negative regulation of osteoblast proliferation [IMP]
- negative regulation of protein catabolic process [ISO]
- negative regulation of protein phosphorylation [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- negative regulation of wound healing [IMP]
- nodal signaling pathway [ISO]
- osteoblast development [IGI]
- osteoblast differentiation [IMP]
- paraxial mesoderm morphogenesis [IMP]
- pericardium development [IGI]
- positive regulation of alkaline phosphatase activity [ISO]
- positive regulation of bone mineralization [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of catenin import into nucleus [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of chondrocyte differentiation [IMP]
- positive regulation of epithelial to mesenchymal transition [ISO]
- positive regulation of focal adhesion assembly [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of interleukin-1 beta production [ISO]
- positive regulation of positive chemotaxis [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of transcription factor import into nucleus [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta3 production [ISO]
- protein stabilization [ISO]
- regulation of binding [IDA]
- regulation of epithelial cell proliferation [IMP]
- regulation of immune response [IMP]
- regulation of striated muscle tissue development [IDA]
- regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transforming growth factor beta receptor signaling pathway [IDA, ISO]
- regulation of transforming growth factor beta2 production [ISO]
- response to hypoxia [ISO]
- signal transduction involved in regulation of gene expression [ISO]
- skeletal system development [IGI]
- somitogenesis [IMP]
- thyroid gland development [IGI]
- transcription from RNA polymerase II promoter [ISO, TAS]
- transdifferentiation [ISO]
- transforming growth factor beta receptor signaling pathway [IDA, ISO]
- transport [ISO]
Gene Ontology Molecular Function- DNA binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- SMAD binding [ISO]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- identical protein binding [ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
- DNA binding [ISO]
- R-SMAD binding [ISO]
- RNA polymerase II activating transcription factor binding [ISO]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [ISO]
- RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity [ISO]
- SMAD binding [ISO]
- bHLH transcription factor binding [ISO]
- beta-catenin binding [ISO]
- chromatin DNA binding [IDA]
- chromatin binding [IDA]
- co-SMAD binding [ISO]
- collagen binding [IPI]
- core promoter proximal region sequence-specific DNA binding [ISO]
- double-stranded DNA binding [IDA]
- enzyme binding [ISO]
- identical protein binding [ISO]
- phosphatase binding [ISO]
- protein binding [IPI]
- protein binding transcription factor activity [ISO]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA, ISO]
- protein kinase binding [ISO]
- sequence-specific DNA binding [ISO]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [ISO]
- transforming growth factor beta receptor binding [ISO]
- transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity [ISO]
- ubiquitin binding [ISO]
- ubiquitin protein ligase binding [ISO]
- zinc ion binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Identification and characterization of a PDZ protein that interacts with activin type II receptors.
We have identified a mouse PDZ protein that interacts with the activin type IIA receptor (ActRIIA), which we named activin receptor-interacting protein 1 (ARIP1). By using yeast two-hybrid screening, we isolated a cDNA clone of ARIP1 from a mouse brain cDNA library. We detected two forms of ARIP1, ARIP1-long and ARIP1-short, which may be produced by alternative splicing. ARIP1-long had ... [more]
J. Biol. Chem. Feb. 25, 2000; 275(8);5485-92 [Pubmed: 10681527]
Throughput
- Low Throughput
Curated By
- BioGRID