DLG1
Gene Ontology Biological Process
- T cell activation [ISO]
- T cell cytokine production [ISO]
- actin filament organization [ISO, ISS]
- activation of protein kinase activity [ISO]
- amyloid precursor protein metabolic process [ISO]
- branching involved in ureteric bud morphogenesis [ISO]
- cell adhesion [IEP]
- cortical actin cytoskeleton organization [ISO, ISS]
- embryonic skeletal system morphogenesis [ISO]
- endothelial cell proliferation [ISO, ISS]
- hard palate development [ISO]
- immunological synapse formation [ISO]
- lens development in camera-type eye [ISO]
- membrane raft organization [ISO]
- negative regulation of T cell proliferation [ISO]
- negative regulation of epithelial cell proliferation [ISO]
- negative regulation of mitotic cell cycle [ISO, ISS]
- negative regulation of protein kinase B signaling [ISO]
- peristalsis [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of potassium ion transport [IMP, ISO]
- protein localization [ISO]
- protein localization to plasma membrane [ISO]
- regulation of membrane potential [ISO]
- regulation of myelination [ISO]
- regulation of protein localization [IMP]
- reproductive structure development [ISO]
- single organismal cell-cell adhesion [ISO, ISS]
- smooth muscle tissue development [ISO]
- tight junction assembly [ISO]
- tissue morphogenesis [ISO]
- ureteric bud development [ISO]
Gene Ontology Molecular Function- L27 domain binding [ISO]
- PDZ domain binding [IPI]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO, ISS]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein kinase binding [IPI, ISO, ISS]
- L27 domain binding [ISO]
- PDZ domain binding [IPI]
- ion channel binding [ISO]
- ionotropic glutamate receptor binding [IPI]
- mitogen-activated protein kinase kinase binding [ISO]
- phosphatase binding [ISO, ISS]
- potassium channel regulator activity [ISO]
- protein C-terminus binding [IPI, ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein kinase binding [IPI, ISO, ISS]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- MPP7-DLG1-LIN7 complex [ISO]
- T-tubule [IDA]
- basal lamina [ISO]
- basal plasma membrane [IDA]
- basolateral plasma membrane [IDA, ISO, ISS]
- cell junction [ISO]
- cell projection membrane [ISO]
- cell-cell junction [ISO]
- cytoplasm [ISO]
- cytoplasmic side of plasma membrane [ISO]
- endoplasmic reticulum [ISO]
- extracellular vesicular exosome [ISO]
- immunological synapse [ISO]
- lateral loop [ISO]
- lateral plasma membrane [ISO]
- membrane raft [ISO]
- microtubule [ISO]
- myelin sheath abaxonal region [ISO]
- neuromuscular junction [ISO]
- neuron projection [IDA]
- node of Ranvier [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA, ISO, TAS]
- postsynaptic membrane [TAS]
- presynaptic membrane [IDA]
- synapse [ISO]
- tight junction [ISO]
KCNA5
Gene Ontology Biological Process
- atrial cardiac muscle cell action potential [ISO]
- membrane hyperpolarization [ISO]
- negative regulation of cytosolic calcium ion concentration [IMP]
- negative regulation of potassium ion transport [ISO]
- positive regulation of G1/S transition of mitotic cell cycle [IDA]
- positive regulation of myoblast proliferation [IDA]
- potassium ion export [ISO]
- potassium ion homeostasis [IMP]
- potassium ion transmembrane transport [IBA, ISO]
- potassium ion transport [IMP, ISO]
- protein oligomerization [IMP]
- regulation of atrial cardiac muscle cell membrane repolarization [ISO]
- regulation of heart rate by cardiac conduction [ISO]
- regulation of membrane potential [IMP, ISO]
- regulation of potassium ion transport [ISO]
- regulation of vasoconstriction [ISO]
- response to hydrogen peroxide [IEP]
- response to hyperoxia [IEP]
- response to hypoxia [IEP]
- response to mechanical stimulus [IEP]
- response to organic substance [IEP]
Gene Ontology Molecular Function- alpha-actinin binding [ISO]
- delayed rectifier potassium channel activity [IBA, ISO]
- outward rectifier potassium channel activity [IMP, ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [IPI]
- scaffold protein binding [ISO]
- voltage-gated potassium channel activity [ISO]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [ISO]
- alpha-actinin binding [ISO]
- delayed rectifier potassium channel activity [IBA, ISO]
- outward rectifier potassium channel activity [IMP, ISO]
- potassium channel inhibitor activity [ISO]
- protein binding [IPI]
- protein kinase binding [ISO]
- receptor binding [IPI]
- scaffold protein binding [ISO]
- voltage-gated potassium channel activity [ISO]
- voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Z disc [IDA]
- endoplasmic reticulum [IDA]
- integral component of membrane [IBA]
- intercalated disc [IDA, ISO]
- intracellular canaliculus [IDA]
- membrane [ISO]
- membrane raft [ISO]
- perinuclear region of cytoplasm [IDA]
- plasma membrane [IDA, ISO]
- voltage-gated potassium channel complex [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5.
The targeting of ion channels to particular membrane microdomains and their organization in macromolecular complexes allow excitable cells to respond efficiently to extracellular signals. In this study, we describe the formation of a complex that contains two scaffolding proteins: caveolin-3 (Cav-3) and a membrane-associated guanylate kinase (MAGUK), SAP97. Complex formation involves the association of Cav-3 with a segment of SAP97 ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| KCNA5 DLG1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID