BAIT

FBXO32

4833442G10Rik, AI430017, ATROGIN1, Gm20361, MAFbx
F-box protein 32
Mus musculus
PREY

EIF4B

2310046H11Rik, AL024095, C85189, Eif4a2
eukaryotic translation initiation factor 4B
GO Process (0)
GO Function (1)
GO Component (0)

Gene Ontology Molecular Function

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Identification of Atrogin-1 targeted proteins during the Myostatin-induced skeletal muscle wasting.

Lokireddy S, Wijesoma IW, Sze SK, McFarlane C, Kambadur R, Sharma M

Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-proteasome mediated system. Myostatin, a member of the TGF-β superfamily, potently inhibits myogenesis by lowering MyoD levels. While Atrogin-1 is up-regulated by Myostatin, it is currently unknown whether Atrogin-1 plays a role in mediating Myostatin signaling to regulate myogenesis. In this report, we have confirmed that Atrogin-1 increasingly interacts ... [more]

Unknown Jun. 06, 2012; 0(0); [Pubmed: 22673621]

Throughput

  • Low Throughput

Curated By

  • BioGRID