BAIT

FBXO32

4833442G10Rik, AI430017, ATROGIN1, Gm20361, MAFbx
F-box protein 32
Mus musculus
PREY

INF2

2610204M08Rik, AA589465, AW125550, EG629699
inverted formin, FH2 and WH2 domain containing
GO Process (2)
GO Function (0)
GO Component (4)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Identification of Atrogin-1 targeted proteins during the Myostatin-induced skeletal muscle wasting.

Lokireddy S, Wijesoma IW, Sze SK, McFarlane C, Kambadur R, Sharma M

Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-proteasome mediated system. Myostatin, a member of the TGF-β superfamily, potently inhibits myogenesis by lowering MyoD levels. While Atrogin-1 is up-regulated by Myostatin, it is currently unknown whether Atrogin-1 plays a role in mediating Myostatin signaling to regulate myogenesis. In this report, we have confirmed that Atrogin-1 increasingly interacts ... [more]

Unknown Jun. 06, 2012; 0(0); [Pubmed: 22673621]

Throughput

  • Low Throughput

Curated By

  • BioGRID