BAIT
FBXO32
4833442G10Rik, AI430017, ATROGIN1, Gm20361, MAFbx
F-box protein 32
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
MYH6
A830009F23Rik, AA517445, Myhc-a, Myhca, alpha-MHC, RP23-171A13.2
myosin, heavy polypeptide 6, cardiac muscle, alpha
GO Process (21)
GO Function (10)
GO Component (9)
Gene Ontology Biological Process
- ATP catabolic process [ISO]
- BMP signaling pathway [IDA]
- actin filament-based movement [IMP]
- adult heart development [IMP, ISO]
- atrial cardiac muscle tissue morphogenesis [ISO]
- canonical Wnt signaling pathway [IDA]
- cardiac muscle fiber development [IMP]
- in utero embryonic development [IMP]
- muscle contraction [ISO]
- muscle filament sliding [ISO]
- myofibril assembly [IMP]
- regulation of ATPase activity [IMP]
- regulation of blood pressure [IMP]
- regulation of heart contraction [IMP]
- regulation of heart growth [IDA]
- regulation of heart rate [IMP, ISO]
- regulation of the force of heart contraction [IMP, ISO]
- sarcomere organization [IMP]
- striated muscle contraction [IMP, ISO]
- ventricular cardiac muscle tissue morphogenesis [ISO]
- visceral muscle development [IMP]
Gene Ontology Molecular Function- ATP binding [ISO]
- ATPase activity [ISO]
- actin-dependent ATPase activity [ISO]
- calcium-dependent ATPase activity [ISO]
- identical protein binding [ISO]
- microfilament motor activity [IMP, ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
- ATP binding [ISO]
- ATPase activity [ISO]
- actin-dependent ATPase activity [ISO]
- calcium-dependent ATPase activity [ISO]
- identical protein binding [ISO]
- microfilament motor activity [IMP, ISO]
- protein binding [IPI]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- protein kinase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Atrogin-1 targeted proteins during the Myostatin-induced skeletal muscle wasting.
Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-proteasome mediated system. Myostatin, a member of the TGF-β superfamily, potently inhibits myogenesis by lowering MyoD levels. While Atrogin-1 is up-regulated by Myostatin, it is currently unknown whether Atrogin-1 plays a role in mediating Myostatin signaling to regulate myogenesis. In this report, we have confirmed that Atrogin-1 increasingly interacts ... [more]
Unknown Jun. 06, 2012; 0(0); [Pubmed: 22673621]
Throughput
- Low Throughput
Curated By
- BioGRID