BAIT
FBXO32
4833442G10Rik, AI430017, ATROGIN1, Gm20361, MAFbx
F-box protein 32
GO Process (4)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Mus musculus
PREY
PIK3CA
6330412C24Rik, caPI3K, p110, p110alpha
phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
GO Process (13)
GO Function (6)
GO Component (5)
Gene Ontology Biological Process
- glucose metabolic process [IMP]
- hypomethylation of CpG island [IDA]
- negative regulation of anoikis [ISO]
- negative regulation of fibroblast apoptotic process [IDA]
- negative regulation of neuron apoptotic process [IMP]
- phosphatidylinositol phosphorylation [IBA, ISO]
- phosphatidylinositol-3-phosphate biosynthetic process [ISO]
- positive regulation of peptidyl-serine phosphorylation [IDA]
- positive regulation of protein kinase activity [IDA]
- protein kinase B signaling [IMP]
- protein phosphorylation [IDA]
- regulation of genetic imprinting [IDA]
- regulation of multicellular organism growth [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Identification of Atrogin-1 targeted proteins during the Myostatin-induced skeletal muscle wasting.
Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-proteasome mediated system. Myostatin, a member of the TGF-β superfamily, potently inhibits myogenesis by lowering MyoD levels. While Atrogin-1 is up-regulated by Myostatin, it is currently unknown whether Atrogin-1 plays a role in mediating Myostatin signaling to regulate myogenesis. In this report, we have confirmed that Atrogin-1 increasingly interacts ... [more]
Unknown Jun. 06, 2012; 0(0); [Pubmed: 22673621]
Throughput
- Low Throughput
Curated By
- BioGRID