BAIT

FBXO32

4833442G10Rik, AI430017, ATROGIN1, Gm20361, MAFbx
F-box protein 32
Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Identification of Atrogin-1 targeted proteins during the Myostatin-induced skeletal muscle wasting.

Lokireddy S, Wijesoma IW, Sze SK, McFarlane C, Kambadur R, Sharma M

Atrogin-1, a muscle-specific E3 ligase, targets MyoD for degradation through the ubiquitin-proteasome mediated system. Myostatin, a member of the TGF-β superfamily, potently inhibits myogenesis by lowering MyoD levels. While Atrogin-1 is up-regulated by Myostatin, it is currently unknown whether Atrogin-1 plays a role in mediating Myostatin signaling to regulate myogenesis. In this report, we have confirmed that Atrogin-1 increasingly interacts ... [more]

Unknown Jun. 06, 2012; 0(0); [Pubmed: 22673621]

Throughput

  • Low Throughput

Curated By

  • BioGRID