RARA
Gene Ontology Biological Process
- Sertoli cell fate commitment [IMP]
- apoptotic cell clearance [ISO]
- bone development [IGI]
- cellular response to estrogen stimulus [ISO]
- cellular response to lipopolysaccharide [IDA]
- cellular response to retinoic acid [ISO]
- chondroblast differentiation [IMP]
- embryonic camera-type eye development [IGI]
- face development [IGI]
- germ cell development [IMP]
- glandular epithelial cell development [IGI]
- growth plate cartilage development [IGI]
- intracellular estrogen receptor signaling pathway [ISO]
- limb development [IGI]
- male gonad development [ISO]
- multicellular organism growth [IGI]
- negative regulation of apoptotic process [IGI]
- negative regulation of cartilage development [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [IGI]
- negative regulation of granulocyte differentiation [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of translation [ISO]
- negative regulation of translational initiation [IDA]
- negative regulation of tumor necrosis factor production [ISO]
- neural tube closure [IGI]
- outflow tract septum morphogenesis [IGI]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of T-helper 2 cell differentiation [ISO]
- positive regulation of binding [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of gene expression [IMP]
- positive regulation of interleukin-13 production [ISO]
- positive regulation of interleukin-4 production [ISO]
- positive regulation of interleukin-5 production [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein phosphorylation [ISO]
- regulation of apoptotic process [ISO]
- regulation of granulocyte differentiation [IMP]
- regulation of myelination [ISO]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [ISO]
- response to ethanol [ISO]
- response to retinoic acid [IMP, ISO]
- retinoic acid receptor signaling pathway [IDA, ISO]
- signal transduction [ISO]
- spermatogenesis [IMP]
- trachea cartilage development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- ureteric bud development [IMP]
- ventricular cardiac muscle cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- chromatin DNA binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- mRNA 5'-UTR binding [ISO]
- phosphatidylinositol 3-kinase regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase B binding [ISO]
- receptor binding [ISO]
- retinoic acid binding [ISO]
- retinoic acid receptor activity [IDA, ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IDA, IGI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IMP]
- translation repressor activity, nucleic acid binding [ISO]
- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- chromatin DNA binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- mRNA 5'-UTR binding [ISO]
- phosphatidylinositol 3-kinase regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase B binding [ISO]
- receptor binding [ISO]
- retinoic acid binding [ISO]
- retinoic acid receptor activity [IDA, ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IDA, IGI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IMP]
- translation repressor activity, nucleic acid binding [ISO]
Gene Ontology Cellular Component
PURA
Gene Ontology Biological Process
- DNA unwinding involved in DNA replication [ISO]
- apoptotic process [NAS]
- cell differentiation [NAS]
- cell proliferation [NAS]
- mitotic cell cycle checkpoint [NAS]
- negative regulation of transcription, DNA-templated [IDA]
- negative regulation of translation [IDA]
- nervous system development [IMP]
- positive regulation of cell proliferation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- double-stranded telomeric DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [IDA]
- DNA binding [IDA]
- SMAD binding [IDA]
- double-stranded DNA binding [IDA]
- double-stranded telomeric DNA binding [ISO]
- poly(A) RNA binding [ISO]
- protein binding [IPI]
- purine-rich negative regulatory element binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- single-stranded DNA binding [IDA]
- transcription factor binding [IPI]
- translation repressor activity, nucleic acid binding [IDA]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.
All-trans-retinoic acid stimulates dendritic growth in hippocampal neurons within minutes by activating mitogen-activated protein kinase and mTOR and increasing dendritic translation of calcium calmodulin-dependent protein kinase II alpha and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole propionate receptor subunit GluR1. Hippocampal neurons express RARalpha in dendrites, and knocking down RARalpha prevents all-trans-retinoic acid effects on dendritic growth. Here we show, by liquid chromatography/mass spectrometry analysis ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| RARA PURA | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | Low | - | BioGRID | - |
Curated By
- BioGRID