BAIT

RARA

Nr1b1, RAR, RARalpha1, RP23-333D2.3
retinoic acid receptor, alpha
GO Process (61)
GO Function (26)
GO Component (8)

Gene Ontology Biological Process

Mus musculus
PREY

NME1

AL024257, NDPK-A, NM23-M1, NM23A, RP23-378I13.1
NME/NM23 nucleoside diphosphate kinase 1
Mus musculus

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

The nuclear transcription factor RARalpha associates with neuronal RNA granules and suppresses translation.

Chen N, Onisko B, Napoli JL

All-trans-retinoic acid stimulates dendritic growth in hippocampal neurons within minutes by activating mitogen-activated protein kinase and mTOR and increasing dendritic translation of calcium calmodulin-dependent protein kinase II alpha and the alpha-amino-3-hydroxyl-5-methyl-4-isoxazole propionate receptor subunit GluR1. Hippocampal neurons express RARalpha in dendrites, and knocking down RARalpha prevents all-trans-retinoic acid effects on dendritic growth. Here we show, by liquid chromatography/mass spectrometry analysis ... [more]

J. Biol. Chem. Jul. 25, 2008; 283(30);20841-7 [Pubmed: 18495661]

Throughput

  • Low Throughput

Curated By

  • BioGRID