FERT2
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [IMP]
- Kit signaling pathway [IMP]
- actin cytoskeleton reorganization [IMP]
- cell adhesion [IMP]
- cell proliferation [ISO]
- cell-cell adhesion mediated by cadherin [IMP]
- cellular response to insulin stimulus [IDA]
- cellular response to macrophage colony-stimulating factor stimulus [ISO]
- cellular response to reactive oxygen species [IMP]
- chemotaxis [IMP]
- cytokine-mediated signaling pathway [ISO]
- diapedesis [IMP]
- epidermal growth factor receptor signaling pathway [IBA]
- extracellular matrix-cell signaling [IMP]
- innate immune response [IBA]
- insulin receptor signaling pathway via phosphatidylinositol 3-kinase [IDA]
- interleukin-6-mediated signaling pathway [ISO]
- microtubule cytoskeleton organization [ISO]
- mitotic cell cycle [ISO]
- negative regulation of mast cell activation involved in immune response [IMP]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- platelet-derived growth factor receptor signaling pathway [IDA]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of actin filament polymerization [ISO]
- positive regulation of cell migration [ISO]
- protein autophosphorylation [IDA, ISO]
- protein phosphorylation [IDA]
- regulation of cell proliferation [IBA]
- regulation of epidermal growth factor receptor signaling pathway [ISO]
- regulation of fibroblast migration [IMP]
- regulation of lamellipodium assembly [ISO]
- regulation of mast cell degranulation [IBA]
- regulation of protein phosphorylation [IMP]
- response to lipopolysaccharide [IMP]
- response to platelet-derived growth factor [IDA]
- signal transduction [IDA]
- substrate adhesion-dependent cell spreading [IMP]
- tyrosine phosphorylation of Stat3 protein [ISO]
Gene Ontology Molecular Function- Rab GTPase binding [ISO]
- actin binding [ISO]
- cadherin binding [ISO]
- cell adhesion molecule binding [ISO]
- cytoskeletal protein binding [ISO]
- epidermal growth factor receptor binding [ISO]
- gamma-catenin binding [ISO]
- lipid binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase 1 binding [IPI]
- receptor binding [IBA]
- Rab GTPase binding [ISO]
- actin binding [ISO]
- cadherin binding [ISO]
- cell adhesion molecule binding [ISO]
- cytoskeletal protein binding [ISO]
- epidermal growth factor receptor binding [ISO]
- gamma-catenin binding [ISO]
- lipid binding [ISO]
- non-membrane spanning protein tyrosine kinase activity [IBA, ISO]
- protein binding [IPI]
- protein kinase activity [IDA]
- protein kinase binding [ISO]
- protein phosphatase 1 binding [IPI]
- receptor binding [IBA]
Gene Ontology Cellular Component
STAT3
Gene Ontology Biological Process
- JAK-STAT cascade [TAS]
- JAK-STAT cascade involved in growth hormone signaling pathway [IDA, ISO]
- astrocyte differentiation [IMP]
- cell proliferation [IDA]
- cellular response to hormone stimulus [ISO]
- cytokine-mediated signaling pathway [NAS]
- eating behavior [IMP]
- eye photoreceptor cell differentiation [IMP]
- glucose homeostasis [IMP]
- growth hormone receptor signaling pathway [ISO]
- interleukin-6-mediated signaling pathway [ISO]
- intracellular receptor signaling pathway [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IGI]
- negative regulation of glycolytic process [IMP]
- negative regulation of hydrogen peroxide biosynthetic process [ISO]
- negative regulation of neuron death [ISO]
- negative regulation of neuron migration [IGI]
- phosphorylation [IDA]
- positive regulation of ATP biosynthetic process [ISO]
- positive regulation of Notch signaling pathway [IMP]
- positive regulation of growth factor dependent skeletal muscle satellite cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- protein import into nucleus [ISO]
- radial glial cell differentiation [IMP]
- regulation of mitochondrial membrane permeability [ISO]
- regulation of multicellular organism growth [IMP]
- regulation of transcription, DNA-templated [ISO, NAS]
- response to cytokine [ISO]
- response to estradiol [ISO]
- sexual reproduction [IMP]
- stem cell maintenance [IMP]
- temperature homeostasis [IMP]
- transcription from RNA polymerase II promoter [IDA, ISO]
Gene Ontology Molecular Function- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
- CCR5 chemokine receptor binding [ISO]
- DNA binding [IDA, ISO]
- RNA polymerase II repressing transcription factor binding [ISO]
- glucocorticoid receptor binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [ISO]
- protein binding [IPI]
- protein dimerization activity [IPI]
- protein kinase binding [IPI]
- protein phosphatase binding [ISO]
- sequence-specific DNA binding [IDA, ISO]
- sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- transcription factor binding [ISO]
- transcription regulatory region DNA binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Fer is a downstream effector of insulin and mediates the activation of signal transducer and activator of transcription 3 in myogenic cells.
Fer is an intracellular tyrosine kinase that associates with signal transducer and activator of transcription 3 (Stat3) in mammalian cells. However, the signaling pathways in which this interaction plays a functional role have not been revealed. Herein, we show that insulin up-regulates the levels of the fer mRNA and Fer protein in myoblasts that undergo insulin-induced myogenic differentiation. Moreover, insulin ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| STAT3 FERT2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID