BAIT
GDF7
BMP12
growth differentiation factor 7
GO Process (23)
GO Function (4)
GO Component (2)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, IGI, ISO]
- SMAD protein signal transduction [IBA]
- activin receptor signaling pathway [ISO]
- axon guidance [IDA]
- branching morphogenesis of an epithelial tube [IMP]
- cell fate commitment [IDA]
- epithelial cell differentiation [IMP]
- forebrain morphogenesis [IMP]
- gland morphogenesis [IMP]
- midbrain development [IMP]
- morphogenesis of an epithelial fold [IMP]
- neural tube development [IMP]
- pathway-restricted SMAD protein phosphorylation [ISO]
- positive regulation of gene expression [IDA]
- positive regulation of neuron differentiation [IDA]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA, ISO]
- positive regulation of tendon cell differentiation [IDA]
- positive regulation of transcription, DNA-templated [ISO]
- regulation of MAPK cascade [IBA]
- regulation of apoptotic process [IBA]
- reproductive structure development [IMP]
- roof plate formation [IMP]
- spinal cord association neuron differentiation [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
BMP7
OP1, RP23-188A4.1
bone morphogenetic protein 7
GO Process (61)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- BMP signaling pathway [IDA, ISO]
- SMAD protein signal transduction [IBA, ISO]
- anatomical structure formation involved in morphogenesis [IMP]
- axon guidance [IDA]
- branching involved in salivary gland morphogenesis [IMP]
- branching morphogenesis of an epithelial tube [IDA]
- camera-type eye morphogenesis [IMP]
- cell development [IDA]
- embryonic camera-type eye morphogenesis [IMP]
- embryonic limb morphogenesis [IGI, IMP]
- embryonic pattern specification [IMP]
- embryonic skeletal joint morphogenesis [IGI, IMP]
- epithelial cell differentiation [IMP]
- eye development [IMP]
- kidney development [IMP]
- mesenchymal cell differentiation [ISO]
- mesenchyme development [IMP]
- mesoderm formation [IGI]
- metanephric mesenchymal cell proliferation involved in metanephros development [IGI]
- metanephric mesenchyme morphogenesis [IGI]
- monocyte aggregation [ISO]
- negative regulation of MAP kinase activity [ISO]
- negative regulation of Notch signaling pathway [IGI]
- negative regulation of cell cycle [ISO]
- negative regulation of cell death [ISO]
- negative regulation of cell proliferation [IMP]
- negative regulation of glomerular mesangial cell proliferation [ISO]
- negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis [IMP]
- negative regulation of mitosis [ISO]
- negative regulation of neurogenesis [IDA]
- negative regulation of neuron differentiation [IMP, ISO]
- negative regulation of phosphorylation [ISO]
- negative regulation of prostatic bud formation [IDA]
- negative regulation of transcription, DNA-templated [ISO]
- nephrogenic mesenchyme morphogenesis [IGI]
- neuron projection morphogenesis [IMP, ISO]
- odontogenesis of dentin-containing tooth [IDA]
- organ morphogenesis [IMP]
- pattern specification process [IMP]
- positive regulation of apoptotic process [IMP]
- positive regulation of bone mineralization [ISO]
- positive regulation of cell death [IGI]
- positive regulation of cell differentiation [IDA]
- positive regulation of dendrite development [ISO]
- positive regulation of heterotypic cell-cell adhesion [ISO]
- positive regulation of hyaluranon cable assembly [ISO]
- positive regulation of neuron differentiation [IDA]
- positive regulation of osteoblast differentiation [ISO]
- positive regulation of pathway-restricted SMAD protein phosphorylation [IBA, ISO]
- positive regulation of peptidyl-threonine phosphorylation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of transcription, DNA-templated [ISO]
- protein localization to nucleus [ISO]
- regulation of MAPK cascade [IBA]
- regulation of branching involved in prostate gland morphogenesis [IMP]
- regulation of pathway-restricted SMAD protein phosphorylation [ISO]
- regulation of phosphorylation [ISO]
- salivary gland morphogenesis [IMP]
- steroid hormone mediated signaling pathway [ISO]
- tube morphogenesis [IDA]
- ureteric bud development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons.
During spinal cord development, commissural neurons extend their axons ventrally, away from the roof plate. The roof plate is the source of a diffusible repellent that orients commissural axons in vitro and, thus, may regulate the trajectory of commissural axons in vivo. Of three Bmps expressed in the roof plate, BMP7, but not BMP6 or GDF7, mimics the roof plate ... [more]
Neuron May. 08, 2003; 38(3);389-401 [Pubmed: 12741987]
Throughput
- Low Throughput
Curated By
- BioGRID