MAPK8
Gene Ontology Biological Process
- JNK cascade [IDA, ISO]
- JUN phosphorylation [IDA, IMP, ISO]
- cellular response to hydrogen peroxide [IDA]
- cellular response to lipopolysaccharide [ISO]
- cellular response to nitric oxide [IMP]
- determination of dorsal identity [ISO]
- inflammatory response [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of protein binding [ISO]
- neuron projection development [ISO]
- ossification [IMP]
- peptidyl-serine phosphorylation [ISO]
- peptidyl-threonine phosphorylation [IMP, ISO]
- positive regulation of DNA replication [ISO]
- positive regulation of apoptotic signaling pathway [IGI]
- positive regulation of cell migration [ISO]
- positive regulation of deacetylase activity [ISO]
- positive regulation of determination of dorsal identity [IDA]
- positive regulation of gene expression [ISO]
- positive regulation of microtubule polymerization [ISO]
- programmed necrotic cell death [IMP]
- protein phosphorylation [IDA]
- regulation of gene expression [IMP]
- regulation of histone deacetylation [ISO]
- regulation of protein localization [ISO]
- regulation of transcription, DNA-templated [ISO]
- response to UV [ISO]
- response to cadmium ion [IGI]
- response to heat [ISO]
- response to hydrogen peroxide [ISO]
- response to osmotic stress [ISO]
- signal transduction [ISO]
Gene Ontology Molecular Function
WWOX
Gene Ontology Biological Process
- cellular response to transforming growth factor beta stimulus [IDA, ISO]
- extrinsic apoptotic signaling pathway [IDA]
- intrinsic apoptotic signaling pathway by p53 class mediator [IGI]
- negative regulation of Wnt signaling pathway [ISO]
- osteoblast differentiation [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- skeletal system morphogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo.
Human WWOX gene encodes a proapoptotic WW domain-containing oxidoreductase WOX1 (also named WWOX, FOR2 or WWOXv1). Apoptotic and stress stimuli activate WOX1 via Tyr33 phosphorylation and nuclear translocation. WOX1 possesses a tetrad NSYK motif in the C-terminal short-chain alcohol dehydrogenase/reductase (SDR) domain, which may bind estrogen and androgen. Here, we determined that 17beta-estradiol (E(2)) activated WOX1, p53 and ERK in ... [more]
Throughput
- Low Throughput
Additional Notes
- figure 6.
Curated By
- BioGRID