PRMT2
Gene Ontology Biological Process
- developmental cell growth [IMP]
- histone arginine methylation [IDA]
- histone methylation [IDA, ISO]
- leptin-mediated signaling pathway [NAS]
- methylation [NAS]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of sequence-specific DNA binding transcription factor activity [IMP]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- peptidyl-arginine N-methylation [IMP]
- peptidyl-arginine methylation, to asymmetrical-dimethyl arginine [IBA]
- positive regulation of apoptotic process [ISO]
- positive regulation of transcription, DNA-templated [IBA, ISO]
- regulation of androgen receptor signaling pathway [ISO]
- regulation of tyrosine phosphorylation of Stat3 protein [NAS]
- response to hypoxia [IDA]
Gene Ontology Molecular Function- androgen receptor binding [ISO]
- beta-catenin binding [IPI]
- estrogen receptor binding [ISO]
- histone methyltransferase activity [ISO]
- histone-arginine N-methyltransferase activity [IDA]
- peroxisome proliferator activated receptor binding [ISO]
- progesterone receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein-arginine N-methyltransferase activity [IMP]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [ISO]
- thyroid hormone receptor binding [ISO]
- transcription coactivator activity [IBA, ISO]
- androgen receptor binding [ISO]
- beta-catenin binding [IPI]
- estrogen receptor binding [ISO]
- histone methyltransferase activity [ISO]
- histone-arginine N-methyltransferase activity [IDA]
- peroxisome proliferator activated receptor binding [ISO]
- progesterone receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein-arginine N-methyltransferase activity [IMP]
- protein-arginine omega-N asymmetric methyltransferase activity [IBA]
- retinoic acid receptor binding [ISO]
- thyroid hormone receptor binding [ISO]
- transcription coactivator activity [IBA, ISO]
RB1
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- cell cycle arrest [IMP]
- cell division [IMP]
- cell morphogenesis involved in neuron differentiation [IMP]
- digestive tract development [IMP]
- enucleate erythrocyte differentiation [IGI]
- glial cell apoptotic process [IMP]
- hepatocyte apoptotic process [IMP, ISO]
- maintenance of mitotic sister chromatid cohesion [ISO]
- myoblast differentiation [ISO]
- negative regulation of G1/S transition of mitotic cell cycle [IMP]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell cycle [IMP]
- negative regulation of cell proliferation [IGI, IMP]
- negative regulation of epithelial cell proliferation [IMP]
- negative regulation of mitotic cell cycle [IGI]
- negative regulation of protein kinase activity [ISO]
- negative regulation of smoothened signaling pathway [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription involved in G1/S transition of mitotic cell cycle [IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- neuron apoptotic process [IMP]
- neuron differentiation [IMP]
- neuron maturation [IMP]
- neuron projection development [IMP]
- positive regulation of macrophage differentiation [IGI]
- positive regulation of mitotic metaphase/anaphase transition [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- protein localization to chromosome, centromeric region [ISO]
- regulation of cell cycle [IMP]
- regulation of cohesin localization to chromatin [ISO]
- regulation of lipid kinase activity [ISO]
- regulation of mitotic cell cycle [ISO]
- sister chromatid biorientation [ISO]
- skeletal muscle cell differentiation [IMP]
- striated muscle cell differentiation [IGI]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The arginine methyltransferase PRMT2 binds RB and regulates E2F function.
The retinoblastoma gene product (RB) is an important regulator of E2F activity. RB recruits a number of proteins, including HDACs, SWI/SNF complex, lysine methyl transferase (SUV39H1) and DNA methyltransferase (DNMT1), all of which negatively regulate E2F activity with RB. Here, we show that RB interacts with PRMT2, a member of the protein arginine methyltransferase family, to regulate E2F activity. PRMT2 ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID