KRAS
Gene Ontology Biological Process
- GTP catabolic process [IGI]
- Ras protein signal transduction [IGI, TAS]
- actin cytoskeleton organization [IGI]
- cytokine-mediated signaling pathway [ISO]
- epithelial tube branching involved in lung morphogenesis [IDA, IGI]
- negative regulation of cell differentiation [IDA]
- negative regulation of neuron apoptotic process [IGI]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of Rac protein signal transduction [IGI]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of gene expression [ISO]
- positive regulation of nitric-oxide synthase activity [ISO]
- positive regulation of protein phosphorylation [ISO]
- regulation of long-term neuronal synaptic plasticity [IGI]
- regulation of synaptic transmission, GABAergic [IGI]
- striated muscle cell differentiation [IGI]
- visual learning [IGI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ZHX2
Gene Ontology Biological Process
- mRNA catabolic process [IDA]
- negative regulation of neuron differentiation [IDA]
- negative regulation of nucleic acid-templated transcription [IBA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of transcription, DNA-templated [IBA]
- somatic stem cell maintenance [IDA]
Gene Ontology Molecular Function
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
Isoprenylcysteine carboxyl methyltransferase (Icmt) methylates the carboxyl-terminal isoprenylcysteine of CAAX proteins (e.g., Ras and Rho proteins). In the case of the Ras proteins, carboxyl methylation is important for targeting of the proteins to the plasma membrane. We hypothesized that a knockout of Icmt would reduce the ability of cells to be transformed by K-Ras. Fibroblasts harboring a floxed Icmt allele ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID