FCGR1
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway [IMP]
- antibody-dependent cellular cytotoxicity [IMP]
- antigen processing and presentation of exogenous antigen [IMP]
- antigen processing and presentation of exogenous peptide antigen via MHC class I [IMP]
- cell surface receptor signaling pathway [IMP]
- defense response to bacterium [IMP]
- phagocytosis, engulfment [IMP]
- phagocytosis, recognition [IMP]
- positive regulation of phagocytosis [IMP]
- positive regulation of type III hypersensitivity [IMP]
- positive regulation of type IIa hypersensitivity [IMP]
- receptor-mediated endocytosis [IMP]
- regulation of immune response [IMP]
- response to bacterium [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HCK
Gene Ontology Biological Process
- cell differentiation [IBA]
- cellular response to peptide hormone stimulus [IBA]
- cytoskeleton organization [IBA]
- defense response to Gram-positive bacterium [IGI]
- innate immune response [IBA]
- negative regulation of apoptotic process [IBA, ISO]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [ISO]
- phagocytosis [IMP]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of cell proliferation [ISO]
- protein autophosphorylation [ISO]
- regulation of cell proliferation [IBA]
- regulation of cell shape [ISO]
- regulation of phagocytosis [IBA, ISO]
- regulation of podosome assembly [IBA, ISO]
- regulation of sequence-specific DNA binding transcription factor activity [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding.
Fc gamma receptor (Fc gammaR)-mediated phagocytosis is known to require tyrosine kinases (TKs). We identified c-Cbl and Cbl-b as proteins that undergo tyrosine phosphorylation during phagocytosis. Cbl-deficient macrophages displayed enhanced Fc gammaR-mediated signaling and phagocytosis. Surprisingly, binding of IgG-coated targets (EIgG) was also enhanced. c-Cbl-deficient macrophages expressed less Fc gammaRIIb, the inhibitory Fc gamma receptor; however, this did not account ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID