BAIT
NTRK1
C80751, Tkr, TrkA, trk
neurotrophic tyrosine kinase, receptor, type 1
GO Process (31)
GO Function (9)
GO Component (12)
Gene Ontology Biological Process
- B cell differentiation [IMP]
- Sertoli cell development [ISO]
- axon guidance [ISO]
- axonogenesis involved in innervation [IMP]
- cellular response to growth factor stimulus [ISO]
- cellular response to nerve growth factor stimulus [ISO]
- cellular response to nicotine [ISO]
- detection of mechanical stimulus involved in sensory perception of pain [ISO]
- detection of temperature stimulus involved in sensory perception of pain [ISO]
- developmental programmed cell death [ISO]
- learning or memory [ISO]
- mechanoreceptor differentiation [IMP]
- negative regulation of neuron apoptotic process [IGI, IMP, ISO]
- negative regulation of neuron death [ISO]
- nerve growth factor signaling pathway [IGI, ISO]
- nervous system development [IDA]
- neurotrophin TRK receptor signaling pathway [ISO]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of angiogenesis [ISO]
- positive regulation of programmed cell death [ISO]
- positive regulation of synaptic transmission, glutamatergic [ISO]
- protein autophosphorylation [ISO]
- protein phosphorylation [IDA, ISO]
- response to activity [ISO]
- response to drug [ISO]
- response to electrical stimulus [ISO]
- response to nicotine [ISO]
- response to nutrient levels [ISO]
- sensory perception of pain [ISO]
- sympathetic nervous system development [IMP]
Gene Ontology Molecular Function- ephrin receptor binding [ISO]
- kinase binding [ISO]
- nerve growth factor binding [ISO]
- nerve growth factor receptor activity [ISO]
- neurotrophin p75 receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
- ephrin receptor binding [ISO]
- kinase binding [ISO]
- nerve growth factor binding [ISO]
- nerve growth factor receptor activity [ISO]
- neurotrophin p75 receptor binding [ISO]
- protein binding [IPI]
- protein homodimerization activity [ISO]
- protein tyrosine kinase activity [ISO]
- transmembrane receptor protein tyrosine kinase activity [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
TRAF6
2310003F17Rik, AI851288, C630032O20Rik, RP23-313G3.1
TNF receptor-associated factor 6
GO Process (44)
GO Function (13)
GO Component (12)
Gene Ontology Biological Process
- I-kappaB kinase/NF-kappaB signaling [IMP]
- JNK cascade [ISO]
- T cell receptor signaling pathway [ISO]
- T-helper 1 type immune response [IMP]
- activation of NF-kappaB-inducing kinase activity [ISO]
- activation of protein kinase activity [ISO]
- antigen processing and presentation of exogenous peptide antigen via MHC class II [IMP]
- bone remodeling [IMP]
- bone resorption [IMP]
- cell development [IMP]
- cellular response to lipopolysaccharide [ISO]
- cytokine-mediated signaling pathway [ISO]
- immune response [IMP]
- interleukin-1-mediated signaling pathway [IMP, ISO]
- myeloid dendritic cell differentiation [IMP]
- negative regulation of transcription from RNA polymerase II promoter [ISO]
- negative regulation of transcription, DNA-templated [ISO]
- neural tube closure [IMP]
- odontogenesis of dentin-containing tooth [IMP]
- organ morphogenesis [IMP]
- ossification [IMP]
- osteoclast differentiation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI, IMP, ISO]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of NF-kappaB transcription factor activity [IMP, ISO]
- positive regulation of T cell cytokine production [ISO]
- positive regulation of T cell proliferation [IMP]
- positive regulation of interleukin-12 biosynthetic process [IMP]
- positive regulation of interleukin-2 production [ISO]
- positive regulation of interleukin-6 biosynthetic process [IMP]
- positive regulation of lipopolysaccharide-mediated signaling pathway [IMP]
- positive regulation of osteoclast differentiation [ISO]
- positive regulation of sequence-specific DNA binding transcription factor activity [ISO]
- positive regulation of smooth muscle cell proliferation [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription regulatory region DNA binding [ISO]
- protein K63-linked ubiquitination [IDA, ISO]
- protein autoubiquitination [ISO, TAS]
- protein complex assembly [ISO]
- protein polyubiquitination [ISO]
- protein ubiquitination [IDA, IGI, IMP]
- regulation of immunoglobulin secretion [IDA]
- response to interleukin-1 [ISO]
- signal transduction [IDA, TAS]
Gene Ontology Molecular Function- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- signal transducer activity [TAS]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, IMP]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
- histone deacetylase binding [ISO]
- mitogen-activated protein kinase kinase kinase binding [ISO]
- protein N-terminus binding [ISO]
- protein binding [IPI]
- protein kinase B binding [ISO]
- protein kinase binding [ISO]
- signal transducer activity [TAS]
- thioesterase binding [ISO]
- tumor necrosis factor receptor binding [ISO]
- ubiquitin conjugating enzyme binding [ISO]
- ubiquitin protein ligase activity [IDA, IMP]
- ubiquitin protein ligase binding [ISO]
- ubiquitin-protein transferase activity [IDA, ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons.
The molecular mechanism and significance of endocytic processes involved in directional axon elongation are not well understood. The Unc-51 family of serine/threonine kinases was shown to be important for axon growth and was also linked to endocytosis, providing an entry point to study this problem. We found that mouse Unc-51-like kinase 1/2 (Ulk1/2) proteins are localized to vesicular structures in ... [more]
Proc. Natl. Acad. Sci. U.S.A. Apr. 03, 2007; 104(14);5842-7 [Pubmed: 17389358]
Throughput
- Low Throughput
Curated By
- BioGRID