BAIT
HRAS
HRAS1, c-H-ras
Harvey rat sarcoma virus oncogene
GO Process (34)
GO Function (3)
GO Component (4)
Gene Ontology Biological Process
- Ras protein signal transduction [IMP, ISO]
- apoptotic process [IMP]
- cell aging [ISO]
- cell cycle arrest [ISO]
- cell proliferation [ISO]
- cellular senescence [ISO]
- endocytosis [ISO]
- intrinsic apoptotic signaling pathway [ISO]
- mitotic cell cycle checkpoint [ISO]
- negative regulation of Rho GTPase activity [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [ISO]
- negative regulation of neuron apoptotic process [ISO]
- positive regulation of DNA replication [IMP, ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of JNK cascade [ISO]
- positive regulation of MAP kinase activity [ISO]
- positive regulation of MAPK cascade [ISO]
- positive regulation of Rac GTPase activity [ISO]
- positive regulation of Ras protein signal transduction [IMP]
- positive regulation of actin cytoskeleton reorganization [ISO]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of gene expression [ISO]
- positive regulation of miRNA metabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of ruffle assembly [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of wound healing [ISO]
- protein heterooligomerization [IPI]
- regulation of long-term neuronal synaptic plasticity [ISO]
- small GTPase mediated signal transduction [ISO]
- social behavior [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
RAF1
v-raf-leukemia viral oncogene 1
GO Process (17)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- MAPK cascade [IDA, IMP]
- activation of MAPKK activity [IDA, IMP, ISO, TAS]
- cell differentiation [ISO]
- death-inducing signaling complex assembly [ISO]
- heart development [IEP]
- intermediate filament cytoskeleton organization [ISO]
- intracellular signal transduction [TAS]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of extrinsic apoptotic signaling pathway via death domain receptors [ISO]
- negative regulation of protein complex assembly [ISO]
- neurotrophin TRK receptor signaling pathway [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- protein phosphorylation [IDA, IMP, TAS]
- response to hypoxia [IDA]
- response to muscle stretch [ISO]
- somatic stem cell maintenance [ISO]
Gene Ontology Molecular Function- ATP binding [IDA]
- MAP kinase kinase kinase activity [IDA, IMP, TAS]
- Ras GTPase binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein serine/threonine kinase activity [ISO]
- small GTPase binding [ISO]
- ATP binding [IDA]
- MAP kinase kinase kinase activity [IDA, IMP, TAS]
- Ras GTPase binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein serine/threonine kinase activity [ISO]
- small GTPase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- cytoplasm [IDA, ISO]
- cytosol [ISO, TAS]
- plasma membrane [IDA, ISO]
- pseudopodium [ISO]
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Interaction between the protein kinase B-Raf and the alpha-subunit of the 11S proteasome regulator.
Protein kinases of the Raf family act as signal-transducing elements downstream of activated cell surface receptors and are involved in the regulation of proliferation, differentiation, and cell survival. Whereas the role of c-Raf-1 as a mitogen-activated protein/extracellular signal-regulated kinase activator within the mitogenic cascade is well established, less is known about the mammalian Raf isoforms A-Raf and B-Raf. Here we ... [more]
Cancer Res. Jul. 15, 1998; 58(14);2986-90 [Pubmed: 9679960]
Throughput
- Low Throughput
Curated By
- BioGRID