PSME1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
BRAF
Gene Ontology Biological Process
- CD4-positive, alpha-beta T cell differentiation [ISO]
- MAPK cascade [IMP]
- activation of MAPKK activity [IDA, IMP]
- alpha-beta T cell differentiation [ISO]
- cell differentiation [ISO]
- cellular response to calcium ion [ISO]
- cellular response to drug [ISO]
- long-term synaptic potentiation [ISO]
- myeloid progenitor cell differentiation [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of endothelial cell apoptotic process [ISO]
- negative regulation of fibroblast migration [ISO]
- negative regulation of neuron apoptotic process [IMP, ISO]
- negative regulation of synaptic vesicle exocytosis [ISO]
- positive T cell selection [ISO]
- positive regulation of ERK1 and ERK2 cascade [IMP, ISO]
- positive regulation of gene expression [ISO]
- positive regulation of peptidyl-serine phosphorylation [ISO]
- positive regulation of stress fiber assembly [ISO]
- positive regulation of substrate adhesion-dependent cell spreading [ISO]
- protein heterooligomerization [IPI]
- protein phosphorylation [IDA, IMP, ISO]
- regulation of cell proliferation [ISO]
- response to cAMP [IMP]
- response to peptide hormone [IMP]
- somatic stem cell maintenance [ISO]
- visual learning [ISO]
Gene Ontology Molecular Function- MAP kinase kinase kinase activity [IDA, IMP]
- calcium ion binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- small GTPase binding [ISO]
- MAP kinase kinase kinase activity [IDA, IMP]
- calcium ion binding [ISO]
- identical protein binding [ISO]
- mitogen-activated protein kinase kinase binding [IMP]
- protein binding [IPI]
- protein heterodimerization activity [IPI]
- protein kinase activity [ISO]
- protein serine/threonine kinase activity [IDA, ISO]
- small GTPase binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Interaction between the protein kinase B-Raf and the alpha-subunit of the 11S proteasome regulator.
Protein kinases of the Raf family act as signal-transducing elements downstream of activated cell surface receptors and are involved in the regulation of proliferation, differentiation, and cell survival. Whereas the role of c-Raf-1 as a mitogen-activated protein/extracellular signal-regulated kinase activator within the mitogenic cascade is well established, less is known about the mammalian Raf isoforms A-Raf and B-Raf. Here we ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BRAF PSME1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| PSME1 BRAF | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID