PSEN1
Gene Ontology Biological Process
- Cajal-Retzius cell differentiation [IMP]
- L-glutamate transport [IMP]
- Notch receptor processing [IMP]
- Notch signaling pathway [IGI, IMP]
- T cell activation involved in immune response [IGI]
- T cell receptor signaling pathway [IGI]
- activation of MAPKK activity [IMP]
- amyloid precursor protein catabolic process [IMP]
- anagen [IGI]
- autophagic vacuole assembly [IMP]
- autophagy [IMP]
- beta-amyloid formation [IMP]
- beta-amyloid metabolic process [IMP]
- blood vessel development [IMP]
- brain development [IMP]
- brain morphogenesis [IGI]
- calcium ion transmembrane transport [ISO]
- calcium ion transport [IBA]
- canonical Wnt signaling pathway [IBA]
- cell fate specification [IGI]
- cellular calcium ion homeostasis [IMP]
- cellular protein metabolic process [IDA, IGI, IMP]
- cellular response to DNA damage stimulus [IMP]
- cerebral cortex cell migration [IMP]
- cerebral cortex development [IMP]
- choline transport [IMP]
- dorsal/ventral neural tube patterning [IGI]
- embryo development [IGI, IMP]
- embryonic limb morphogenesis [IGI]
- endoplasmic reticulum calcium ion homeostasis [IGI, IMP, ISO]
- epithelial cell proliferation [IGI]
- forebrain development [IGI]
- heart development [IMP]
- heart looping [IGI]
- hematopoietic progenitor cell differentiation [IGI]
- learning or memory [IGI]
- locomotion [IGI]
- membrane protein ectodomain proteolysis [IBA, ISO]
- memory [IGI, IMP]
- mitochondrial transport [IMP]
- myeloid dendritic cell differentiation [IMP]
- myeloid leukocyte differentiation [IGI]
- negative regulation of apoptotic process [IDA, ISO]
- negative regulation of apoptotic signaling pathway [IGI]
- negative regulation of axonogenesis [IMP]
- negative regulation of epidermal growth factor-activated receptor activity [IMP]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of protein kinase activity [IMP]
- negative regulation of protein phosphorylation [IGI]
- negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of ubiquitin-protein transferase activity [IMP]
- neurogenesis [IMP]
- neuron apoptotic process [IGI]
- neuron development [IMP]
- neuron differentiation [IMP]
- neuron migration [IMP]
- positive regulation of MAP kinase activity [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of catalytic activity [ISO]
- positive regulation of coagulation [IMP]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IMP]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of receptor recycling [IMP]
- post-embryonic development [IMP]
- protein glycosylation [IMP]
- protein maturation [IGI]
- protein processing [IMP, ISO]
- protein transport [IGI]
- proteolysis [IGI]
- regulation of epidermal growth factor-activated receptor activity [IGI]
- regulation of phosphorylation [ISO]
- regulation of protein binding [IGI]
- regulation of resting membrane potential [IMP]
- regulation of synaptic plasticity [IGI, IMP]
- regulation of synaptic transmission, glutamatergic [IMP]
- response to oxidative stress [IGI, IMP]
- segmentation [IMP]
- single organismal cell-cell adhesion [ISO]
- skeletal system morphogenesis [IMP]
- skin morphogenesis [IMP]
- smooth endoplasmic reticulum calcium ion homeostasis [IGI]
- somitogenesis [IGI, IMP]
- synaptic vesicle targeting [IMP]
- thymus development [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA, ISO]
- Z disc [IBA]
- apical plasma membrane [IBA]
- axon [IDA]
- cell [IGI]
- cell cortex [IBA]
- cell surface [IBA, ISO]
- centrosome [ISO]
- ciliary rootlet [IDA]
- cytoplasmic vesicle [IDA]
- dendrite [IDA]
- dendritic shaft [IDA]
- endoplasmic reticulum [IDA, IMP, ISO]
- gamma-secretase complex [ISO]
- growth cone [IDA]
- integral component of plasma membrane [IBA, ISO]
- intracellular [IDA, IMP]
- kinetochore [ISO]
- lysosomal membrane [IBA, ISO]
- membrane [IDA]
- membrane raft [IBA, ISO]
- membrane-bounded organelle [IDA]
- mitochondrial inner membrane [IBA, ISO]
- mitochondrion [ISO]
- neuromuscular junction [IBA, ISO]
- neuron projection [ISO]
- neuronal cell body [IDA]
- nuclear membrane [ISO]
- nuclear outer membrane [ISO]
- nucleus [IDA]
- perinuclear region of cytoplasm [IBA]
- plasma membrane [IDA]
- protein complex [ISO]
- rough endoplasmic reticulum [ISO]
- smooth endoplasmic reticulum [IGI, ISO]
GRIN1
Gene Ontology Biological Process
- adult locomotory behavior [IMP]
- associative learning [IMP]
- calcium ion homeostasis [IDA]
- calcium ion transmembrane transport [IGI, ISO]
- calcium ion transport [IDA, IMP]
- cation transport [IGI, ISO]
- cellular calcium ion homeostasis [IMP]
- cerebral cortex development [IMP]
- conditioned taste aversion [IMP]
- ion transmembrane transport [IMP]
- ionotropic glutamate receptor signaling pathway [IDA, IGI, ISO]
- learning [IMP]
- learning or memory [IMP]
- long-term memory [IMP]
- male mating behavior [IMP]
- memory [IMP]
- negative regulation of neuron apoptotic process [IGI, IMP]
- neuromuscular process [IMP]
- olfactory learning [IMP]
- pons maturation [IMP]
- positive regulation of apoptotic process [IGI]
- positive regulation of cell death [ISO]
- positive regulation of excitatory postsynaptic membrane potential [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- prepulse inhibition [IMP]
- propylene metabolic process [IDA]
- protein tetramerization [ISO]
- regulation of axonogenesis [IMP]
- regulation of cell communication [IMP]
- regulation of dendrite morphogenesis [IMP]
- regulation of excitatory postsynaptic membrane potential [IGI, IMP]
- regulation of ion transmembrane transport [ISO]
- regulation of long-term neuronal synaptic plasticity [IMP]
- regulation of membrane potential [IDA, IMP, ISO]
- regulation of neuron apoptotic process [IGI, IMP]
- regulation of neuronal synaptic plasticity [IMP]
- regulation of respiratory gaseous exchange [IMP]
- regulation of synapse assembly [IMP]
- regulation of synaptic plasticity [IMP]
- respiratory gaseous exchange [IMP]
- response to amphetamine [IGI, IMP]
- response to ethanol [ISO]
- response to morphine [IMP]
- rhythmic process [ISO]
- sensory perception of pain [IMP]
- social behavior [IMP]
- startle response [IMP]
- suckling behavior [IMP]
- synaptic transmission [TAS]
- synaptic transmission, glutamatergic [IMP]
- visual learning [IGI, IMP]
Gene Ontology Molecular Function- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- calcium channel activity [IDA, IGI, ISO]
- calcium ion binding [IDA]
- calmodulin binding [IDA]
- cation channel activity [IGI]
- enzyme binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- glycine binding [IMP, ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [ISO]
- N-methyl-D-aspartate selective glutamate receptor activity [IDA, IGI, IMP, ISO]
- calcium channel activity [IDA, IGI, ISO]
- calcium ion binding [IDA]
- calmodulin binding [IDA]
- cation channel activity [IGI]
- enzyme binding [ISO]
- extracellular-glutamate-gated ion channel activity [IBA]
- glutamate binding [ISO]
- glutamate receptor binding [ISO]
- glycine binding [IMP, ISO]
- ionotropic glutamate receptor activity [ISO]
- neurotransmitter binding [ISO]
- protein binding [IPI]
- protein dimerization activity [ISO]
- protein heterodimerization activity [ISO]
- receptor binding [IPI, ISO]
- voltage-gated cation channel activity [ISO]
Gene Ontology Cellular Component
- N-methyl-D-aspartate selective glutamate receptor complex [IPI, ISO]
- cell [IMP]
- cell surface [IDA]
- cytoplasm [IDA]
- dendrite [IDA, ISO]
- dendrite membrane [ISO]
- dendritic spine [IDA, ISO]
- endoplasmic reticulum [IDA]
- excitatory synapse [ISO]
- growth cone [NAS]
- integral component of plasma membrane [ISO]
- membrane [IC, IDA]
- neuronal postsynaptic density [IDA]
- postsynaptic density [IDA, ISO]
- postsynaptic membrane [IDA]
- synapse [IDA, ISO]
- synaptic cleft [ISO]
- synaptic vesicle [IDA]
- terminal bouton [ISO]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration.
Mutations in presenilins are the major cause of familial Alzheimer's disease, but the pathogenic mechanism by which presenilin mutations cause memory loss and neurodegeneration remains unclear. Here we demonstrate that conditional double knockout mice lacking both presenilins in the postnatal forebrain exhibit impairments in hippocampal memory and synaptic plasticity. These deficits are associated with specific reductions in NMDA receptor-mediated responses ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID