APBB1
Gene Ontology Biological Process
- actin filament-based movement [NAS]
- axon guidance [IGI]
- cell cycle arrest [IDA]
- cellular response to DNA damage stimulus [IDA, ISO]
- double-strand break repair [IMP, ISO]
- extracellular matrix organization [IGI]
- histone H4 acetylation [ISO]
- negative regulation of cell growth [IDA]
- negative regulation of neuron differentiation [IMP]
- negative regulation of thymidylate synthase biosynthetic process [IDA]
- neuron migration [IGI]
- positive regulation of DNA repair [IMP, ISO]
- positive regulation of apoptotic process [ISO]
- positive regulation of protein secretion [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein stabilization [NAS]
- regulation of transcription, DNA-templated [IDA]
- visual learning [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ENAH
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Far Western
An interaction is detected between a protein immobilized on a membrane and a purified protein probe.
Publication
The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.
The neural protein FE65 contains two types of protein-protein interaction modules: one WW binding domain and two phosphotyrosine binding domains. The carboxyl-terminal phosphotyrosine binding domain of FE65 interacts in vivo with the beta-amyloid precursor protein, which is implicated in Alzheimer disease. To understand the function of this adapter protein, we identified binding partners for the FE65 WW domain. Proline-rich sequences ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| APBB1 ENAH | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID